| William Petersen | ... | Gil Grissom (183 episodes, 2000-2008) |
| Marg Helgenberger | ... | Catherine Willows (183 episodes, 2000-2008) |
| Gary Dourdan | ... | Warrick Brown (183 episodes, 2000-2008) |
| George Eads | ... | Nick Stokes (183 episodes, 2000-2008) |
 | Paul Guilfoyle | ... | Captain Jim Brass / ... (183 episodes, 2000-2008) |
| Eric Szmanda | ... | Greg Sanders (181 episodes, 2000-2008) |
| Robert David Hall | ... | Dr. Al Robbins / ... (176 episodes, 2000-2008) |
| Jorja Fox | ... | Sara Sidle (170 episodes, 2000-2007) |
| David Berman | ... | David Phillips (135 episodes, 2000-2008) |
| Wallace Langham | ... | David Hodges / ... (96 episodes, 2003-2008) |
| Archie Kao | ... | Archie Johnson / ... (65 episodes, 2001-2008) |
| Louise Lombard | ... | Sofia Curtis / ... (52 episodes, 2004-2007) |
| Liz Vassey | ... | Wendy Simms (34 episodes, 2005-2008) |
| Gerald McCullouch | ... | Bobby Dawson (32 episodes, 2000-2008) |
| Joseph Patrick Kelly | ... | Officer Joe Metcalf / ... (29 episodes, 2000-2008) |
| Larry Mitchell | ... | Officer Mitchell (28 episodes, 2005-2008) |
| Skip O'Brien | ... | Detective Ray O'Riley / ... (24 episodes, 2000-2003) |
| Marc Vann | ... | Conrad Ecklie (23 episodes, 2000-2007) |
| Jon Wellner | ... | Henry Andrews / ... (21 episodes, 2005-2008) |
| Sheeri Rappaport | ... | Mandy Webster (20 episodes, 2000-2008) |
| Alex Carter | ... | Detective Vartann (18 episodes, 2003-2006) |
| Geoffrey Rivas | ... | Detective Sam Vega (16 episodes, 2001-2007) |
| Paula Francis | ... | Herself - News Anchor / ... (16 episodes, 2000-2008) |
| Romy Rosemont | ... | Jacqui Franco (14 episodes, 2002-2005) |
| Palmer Davis | ... | Attorney Margaret Finn / ... (13 episodes, 2001-2006) |
| Eric Stonestreet | ... | Ronnie Litre (13 episodes, 2001-2005) |
| Aisha Tyler | ... | Mia Dickerson (12 episodes, 2004-2005) |
| Terry Bozeman | ... | Attorney Brad Lewis / ... (12 episodes, 2001-2007) |
| Victoria Prescott | ... | Judy Tremont (12 episodes, 2002-2007) |
| Conor O'Farrell | ... | Undersheriff Jeffrey McKeen / ... (11 episodes, 2005-2008) |
| Larry Sullivan | ... | Officer Akers / ... (10 episodes, 2003-2008) |
| Jeffrey D. Sams | ... | Detective Cyrus Lockwood (9 episodes, 2002-2003) |
| Madison McReynolds | ... | Lindsey Willows (9 episodes, 2000-2005) |
| Scott Wilson | ... | Sam Braun (9 episodes, 2001-2006) |
| James Patrick Stuart | ... | Attorney Adam Matthews (8 episodes, 2003-2005) |
| José Zúñiga | ... | Detective Cavaliere (8 episodes, 2004-2005) |
| Christopher Wiehl | ... | Hank Peddigrew (7 episodes, 2001-2003) |
| Glenn Morshower | ... | Sheriff Brian Mobley (7 episodes, 2000-2001) |
| Erik Jensen | ... | Asst. Dist. Atty. Jeffrey Sinclair / ... (7 episodes, 2003-2007) |
| Judith Scott | ... | Dr. Jenna Williams (6 episodes, 2000-2001) |
| Edmund Wyson | ... | Officer Devine / ... (6 episodes, 2000-2004) |
| Ty Upshaw | ... | Police Officer / ... (6 episodes, 2002-2005) |
| Eden Marie James | ... | Civilian Employee (6 episodes, 2007) |
| Xander Berkeley | ... | Sheriff Rory Atwater (5 episodes, 2003-2004) |
| Pamela Gidley | ... | Teri Miller (5 episodes, 2000-2002) |
| Tom Gallop | ... | Attorney Randy Painter / ... (5 episodes, 2001-2003) |
| Wayne Wilderson | ... | Paramedic / ... (5 episodes, 2001-2005) |
| Vincent Duvall | ... | Lt. Jack Parker / ... (5 episodes, 2006-2008) |
| Timothy Carhart | ... | Eddie Willows (4 episodes, 2000-2003) |
| Kelly Connell | ... | Randy Gesek, Funeral Director (4 episodes, 2000-2001) |
| Nicholas Lea | ... | Chris Bezich (4 episodes, 2004) |
| Tony Amendola | ... | Professor Rambar / ... (4 episodes, 2001-2006) |
| Mark Collver | ... | Detective B. Evans (4 episodes, 2000-2001) |
| Aasif Mandvi | ... | Dr. Leever (4 episodes, 2000-2006) |
| Meredith Scott Lynn | ... | Attorney Carol Allred (4 episodes, 2005-2006) |
| Greg Collins | ... | Officer Arvington (4 episodes, 2000-2001) |
| Doan Ly | ... | Jessie Menken (4 episodes, 2003-2005) |
| Maureen Muldoon | ... | Reporter Lynda Darby (4 episodes, 2001-2003) |
| Brandon Kirsch | ... | Officer Almada (4 episodes, 2003) |
| Melinda Clarke | ... | Lady Heather (4 episodes, 2001-2007) |
| Liev Schreiber | ... | Michael Keppler (4 episodes, 2007) |
| Michael Bryan French | ... | Dr. Franks / ... (4 episodes, 2004-2006) |
| William Allen Young | ... | Duane McWane (4 episodes, 2005-2007) |
| Paul Ganus | ... | Police Officer (4 episodes, 2004-2006) |
| Jim Jenkins | ... | Reporter #1 / ... (4 episodes, 2001-2004) |
| Barry Sigismondi | ... | Cruiser Cop / ... (4 episodes, 2003-2005) |
| Charley Rossman | ... | Officer Beltran / ... (4 episodes, 2001-2007) |
| Scott DeFoe | ... | SWAT Commander / ... (4 episodes, 2003-2007) |
| Jessica Lucas | ... | Ronnie Lake (4 episodes, 2007) |
| Brad Johnson | ... | Paul Newsome, District Engineer (3 episodes, 2001) |
| Harrison Young | ... | Judge Cohen (3 episodes, 2000) |
| Anita Gillette | ... | Lily Flynn (3 episodes, 2005-2007) |
| Matt O'Toole | ... | Paul Millander / ... (3 episodes, 2000-2002) |
| Paul Francis | ... | Rich (3 episodes, 2003) |
| Aimee Graham | ... | Kelly Gordon (3 episodes, 2005-2006) |
| Mark Derwin | ... | James Mandelbaum / ... (3 episodes, 2004-2006) |
| Andrea Roth | ... | Woman Officer (3 episodes, 2003-2004) |
| Paul Terrell Clayton | ... | Homicide Detective Kane (3 episodes, 2000-2001) |
| Tina Lifford | ... | Judge Witherspoon (3 episodes, 2004-2005) |
| Candace Edwards | ... | Medical Examiner (3 episodes, 2002-2003) |
| Leslie Bega | ... | Leah (3 episodes, 2002-2003) |
| Jason Segel | ... | Neil Jansen (3 episodes, 2004-2005) |
| John Churchill | ... | Shibley (3 episodes, 2000-2001) |
| Mary Jo Mrochinski | ... | Ms. Karpell / ... (3 episodes, 2002-2005) |
| Anthony E. Zuiker | ... | Casino Cashier / ... (3 episodes, 2001-2004) |
| Tom Warden | ... | Himself / ... (3 episodes, 2003-2005) |
| Krista Allen | ... | Kristy Hopkins (3 episodes, 2000-2001) |
| Lorraine Toussaint | ... | Marla James / ... (3 episodes, 2006-2007) |
| John Capodice | ... | Lou Gedda (3 episodes, 2007-2008) |
| Vicellous Reon Shannon | ... | Aaron James / ... (3 episodes, 2006-2007) |
| Method Man | ... | Drops (3 episodes, 2006-2008) |
| A Martinez | ... | Assemblyman Danilo Zamesca (3 episodes, 2005-2007) |
| Debra Wilson | ... | Divine (3 episodes, 2004-2007) |
| Mitchell Fink | ... | Paramedic Fink (3 episodes, 2005-2006) |
| Currie Graham | ... | Willy Cutler / ... (3 episodes, 2001-2006) |
| Dayton Callie | ... | Ernie Dell (3 episodes, 2006-2007) |
| Danny Bonaduce | ... | Izzy Delancey (3 episodes, 2006) |
| Meta Golding | ... | Tina Brown / ... (3 episodes, 2001-2006) |
| Kay Panabaker | ... | Lindsey Willows (3 episodes, 2006-2007) |
| John Everlove | ... | Paramedic / ... (3 episodes, 2006-2007) |
| Jon K. Farless | ... | CSI Tech #1 / ... (3 episodes, 2005-2007) |
| Willie Macc | ... | Demetrius James (3 episodes, 2006-2007) |
| Kelley Daugherty | ... | Marianne / ... (3 episodes, 2006) |
| Colin Kim | ... | Officer Choi (3 episodes, 2007-2008) |
| John Beasley | ... | Charles Moore (2 episodes, 2000-2001) |
| Barbara Tarbuck | ... | Paige Harmon (2 episodes, 2000) |
| Brigid Brannagh | ... | Tammy Felton / ... (2 episodes, 2001) |
| Reginald VelJohnson | ... | Dr. Philip Kane (2 episodes, 2001) |
| David Andrews | ... | Officer Fromansky (2 episodes, 2003-2004) |
| John Doman | ... | Judge Slater (2 episodes, 2003) |
| Sam Jones III | ... | James Moore (2 episodes, 2000-2001) |
| Andrew Prine | ... | Rodger Stokes (2 episodes, 2005) |
| Susan Gibney | ... | Charlotte Meridian (2 episodes, 2000-2001) |
| Tamara Clatterbuck | ... | Michelle Acheson / ... (2 episodes, 2001-2005) |
| Eddie Jemison | ... | Mr. Dorsey / ... (2 episodes, 2002-2004) |
| Tom Wright | ... | Jake Daniels / ... (2 episodes, 2001-2007) |
| Larry Holden | ... | Darin Hanson (2 episodes, 2001) |
| Jonathan Banks | ... | Bobby Jensen (2 episodes, 2004-2006) |
| David Lee Smith | ... | Cody Lewis (2 episodes, 2002-2004) |
| Chandra West | ... | Holly Gribbs (2 episodes, 2000) |
| Raymond Cruz | ... | Donald Balboa / ... (2 episodes, 2003-2008) |
| Jim Beaver | ... | Stanley Tanner (2 episodes, 2006) |
| Blake Lindsley | ... | Charlotte Summerville / ... (2 episodes, 2000-2006) |
| Nichole Hiltz | ... | Dancer / ... (2 episodes, 2001-2003) |
| Lennie Loftin | ... | Bomb Squad Leader / ... (2 episodes, 2004-2005) |
| Keri Lynn Pratt | ... | Anna Leah (2 episodes, 2001-2006) |
| Scott Alan Smith | ... | Stuart Gardner (2 episodes, 2003) |
| James Hiroyuki Liao | ... | Eric Hong / ... (2 episodes, 2007-2008) |
| Rebecca Budig | ... | Joanna 'Candy' Krumsky (2 episodes, 2007) |
| Tom Beyer | ... | L. Collins (2 episodes, 2000-2001) |
| Kevin Will | ... | Male Parent / ... (2 episodes, 2001-2002) |
| Michael Ensign | ... | Judge Brenner / ... (2 episodes, 2002-2003) |
| Bobby Hosea | ... | Negotiator / ... (2 episodes, 2004-2008) |
| Dennis Christopher | ... | Homeless Guy / ... (2 episodes, 2007) |
| David Meunier | ... | Barry Lawrence / ... (2 episodes, 2002-2008) |
| Catherine MacNeal | ... | Grissom's Doctor (2 episodes, 2002) |
| Jeff Sugarman | ... | Dr. Mulligan (2 episodes, 2004-2006) |
| Kevin Cooney | ... | Captain Murdle / ... (2 episodes, 2000-2004) |
| Tim Kelleher | ... | IAB Investigator / ... (2 episodes, 2004-2007) |
| Andy Buckley | ... | Jason Hendler / ... (2 episodes, 2000-2005) |
| Michael Delano | ... | Ted Beaton / ... (2 episodes, 2000-2002) |
| Shonda Farr | ... | Lori (2 episodes, 2001-2006) |
| Laurie Fortier | ... | Janine Wood / ... (2 episodes, 2002-2005) |
| Sarah Buxton | ... | Lana Davis, Juror / ... (2 episodes, 2004) |
| Rocky McMurray | ... | Construction Worker / ... (2 episodes, 2000-2001) |
| Jonathan T. Floyd | ... | EMS #1 / ... (2 episodes, 2000) |
| Garland Whitt | ... | Jerrod Cooper (2 episodes, 2000) |
| Arlene Malinowski | ... | Halley the Interpreter / ... (2 episodes, 2001-2002) |
| Victor Bevine | ... | John Mathers (2 episodes, 2002-2004) |
| Paul Carafotes | ... | Casino Manager / ... (2 episodes, 2004-2006) |
| Joe Michael Burke | ... | Carl Kelly (2 episodes, 2000-2003) |
| Nick Searcy | ... | Sheriff Burdick (2 episodes, 2005-2006) |
| Susan Santiago | ... | Attorney Kimberly Cassano / ... (2 episodes, 2000) |
| Larry Clarke | ... | Detective Sulik (2 episodes, 2002-2003) |
| Sandy Martin | ... | Female Trucker / ... (2 episodes, 2001-2007) |
| Jamie McShane | ... | Eddie Vonner / ... (2 episodes, 2001-2005) |
| Marc Valera | ... | Parking Valet / ... (2 episodes, 2001-2003) |
| Frank Novak | ... | Clark County Judge / ... (2 episodes, 2002-2003) |
| Alan Rosenberg | ... | Adam Novak (2 episodes, 2005-2007) |
| Lamont Thompson | ... | Line-Up Officer / ... (2 episodes, 2004-2005) |
| Todd Jeffries | ... | Foreman (2 episodes, 2003-2007) |
| Bunnie Rivera | ... | Housekeeper / ... (2 episodes, 2004-2005) |
| Jeff Snyder | ... | Officer Smith (2 episodes, 2000) |
| J. Marvin Campbell | ... | HazMat Tech (2 episodes, 2002-2005) |
| C.C. Carr | ... | Female Media / ... (2 episodes, 2001-2002) |
| Danica Stewart | ... | Nikki Jensen / ... (2 episodes, 2001-2004) |
| Sandra Hess | ... | Mandy Klinefeld (2 episodes, 2003) |
| Brenda Canela | ... | Gloria Torres / ... (2 episodes, 2005-2006) |
| Todd E. Slayton | ... | Paramedic (2 episodes, 2002-2003) |
| Greg Anthony | ... | Kevin Staniland / ... (2 episodes, 2005) |
| Patricia Bethune | ... | Teacher / ... (2 episodes, 2003-2005) |
| Mark Lentry | ... | Calvin McBride / ... (2 episodes, 2002-2004) |
| Christopher Allen Nelson | ... | Officer Michaels (2 episodes, 2005) |
| Claude Shires | ... | Lou Barnes / ... (2 episodes, 2004-2005) |
| Jonny Miller | ... | Officer Clark / ... (2 episodes, 2005-2006) |
| Teal Redmann | ... | Ellie 'Jersey' Brass / ... (2 episodes, 2005-2006) |
| Luis Antonio Ramos | ... | Jesus Cardenas / ... (2 episodes, 2003-2007) |
| Rudolf Martin | ... | Cameron Klinefeld (2 episodes, 2003) |
| Juliette Goglia | ... | Hannah West (2 episodes, 2006-2007) |
| Gina Hecht | ... | Donna Wetzel / ... (2 episodes, 2001-2007) |
| Nestor Serrano | ... | Detective Ortega (2 episodes, 2005) |
| Douglas Smith | ... | Marlon West (2 episodes, 2006-2007) |
| Steve Ryan | ... | Sergeant Adams (2 episodes, 2005) |
| Kevin Rahm | ... | Joe Hirschoff (2 episodes, 2006) |
| Sam Witwer | ... | Officer Casella (2 episodes, 2007-2008) |
| Vince Vieluf | ... | Connor Foster (2 episodes, 2003-2007) |
| Rick Worthy | ... | Dr. Stewart (2 episodes, 2003-2006) |
| Darris Love | ... | Ezekiel Holstein (2 episodes, 2007) |
| Dig Wayne | ... | Joe Baker / ... (2 episodes, 2002-2007) |
| Clark Middleton | ... | Delivery Man's Attorney / ... (2 episodes, 2005-2006) |
| Brennan Elliott | ... | Sergeant Carroll (2 episodes, 2005) |
| Kayla Mae Maloney | ... | Amy McCarty (2 episodes, 2007) |
| Jack McGee | ... | Richard O'Malley / ... (2 episodes, 2002-2008) |
| Colby French | ... | Officer Davis (2 episodes, 2005) |
| Shelli Bergh | ... | Jessica Hall / ... (2 episodes, 2001-2007) |
| Nicole Cannon | ... | Floor Manager / ... (2 episodes, 2001-2007) |
| Daniel Bess | ... | Officer Bell (2 episodes, 2005) |
| Joe Reegan | ... | Arnie Clifton (2 episodes, 2006) |
| Kim Delgado | ... | Discharge Guard / ... (2 episodes, 2002-2008) |
| Adrian R'Mante | ... | Paramedic Rivera (2 episodes, 2006-2007) |
| Michael Azria | ... | California Kid (2 episodes, 2003) |
| Bre Blair | ... | Tracy (2 episodes, 2005) |
| Lydia Blanco | ... | Maid (2 episodes, 2003) |
| Bill Jacobson | ... | Deputy Irons / ... (2 episodes, 2003-2005) |
| Patricia Heller | ... | ER Nurse / ... (2 episodes, 2005-2006) |
| Nick Trasente | ... | Croupier / ... (2 episodes, 2001-2004) |
| Michael Lopez | ... | Bill Nolin / ... (2 episodes, 2003) |
| Breck Wilson | ... | Fred Laggerman (2 episodes, 2003) |
| Seth Michaels | ... | Stuckey's Brother (2 episodes, 2005) |
| Sophia Santi | ... | Stuckey's Mother (2 episodes, 2005) |
| Edwin Villa | ... | Jose 'Lucky' Fausto (2 episodes, 2005) |
| Christopher J. Buzzell | ... | Police Officer (2 episodes, 2002-2003) |
| Lonnie Paul | ... | Gothic Dancer / ... (2 episodes, 2003-2004) |
| James McMann | ... | Casino Patron / ... (2 episodes, 2005) |
| Carla Orlandi | ... | Bubbles Manleigh / ... (2 episodes, 2006-2007) |
| Juliana Bellinger | ... | Penny Garden (2 episodes, 2006) |
| Kandiss Edmundson | ... | Female Hostage (2 episodes, 2006) |
| Edward C. Hayes | ... | Robert O'Brien (2 episodes, 2006) |
| Omar Leyva | ... | Vasco Ruiz (2 episodes, 2006) |
| Michael Milhoan | ... | Bartender (2 episodes, 2006) |
| Richie Rayfield | ... |
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