Meemaw intervenes when Sheldon gets jealous of Dr. Sturgis bonding with Paige, another 10-year-old genius. In the meantime, Mary invites Paige's family over for a play date.
Mary clashes with Sheldon's drama teacher over plans for a Halloween fundraiser for the church. Also, Georgie falls for a rebellious teenage girl that Sheldon is tutoring.
Sheldon gets into trouble with fellow child genius Paige at the science museum; George Sr. is forced to play therapist to Paige's bickering parents; and Mary, Georgie, and Missy help Meemaw with a garage sale.
Sheldon tries to act like a kid after learning that people with stunted childhoods can become social outcasts; Meemaw teaches Dr. Sturgis how to drive, putting their relationship to the test.
When Sheldon spends a few days at the hospital, he turns out to be the world's worst patient. Missy gets a taste of what it would be like if she didn't have a twin.
Sheldon attempts to build a nuclear reactor. Also, a university cocktail party gets heated when Dr. Sturgis' colleague, Dr. Linkletter, flirts with Meemaw, and Georgie is heartbroken when he learns Veronica has a boyfriend.
Sheldon and Dr. Sturgis have their first fight when Dr. Sturgis marks an answer wrong on Sheldon's test; Mary takes over for Pastor Jeff when he's out sick.
Sheldon's boycott of his favourite bread company goes out of control. Meanwhile, Georgie tries to console Veronica after breaking up with her boyfriend.
Sheldon gets inspired by his hero Albert Einstein and tries to play violin. Mary thinks that she is pregnant and goes to buy pregnancy test with Meemaw.
Sheldon moves in with Dr. Sturgis for the weekend to see what it's like in college and a lonely Mary tries to bond with the other Coopers during Sheldon's absence.
The Coopers help Pastor Jeff through a rough patch in his marriage. Also, Sheldon pressures church members for donations when Mary takes him to work for a day.
Sheldon invites the entire school to a party for the Nobel Prize announcements. Also, Meemaw learns more about Dr. Sturgis' past, and Georgie's desire for cable TV leads to a standoff between him and George Sr.