The second season starts with Joel still in the asylum trying to make his way back home. Sheila is still locked in the basement. Abby and Eric continue the search for Serbian bile to finish the serum.
Joe and Sheila brainstorm how to eliminate rival realtors from the competition without resorting to murder. Abby and Eric attempt to cover their tracks.
Joel decides how to handle his role in Sheila's new lifestyle. Eric has trouble with a girl. Abby deals with her rage. And everyone must try to be "normal."
Abby has a date, which is hard for Eric to deal with. Sheila is having trouble getting along with her boss. Joel does some research and pays colonel Ted a visit to find out if he is also undead.
Joel goes looking for the third undead with hope it will prove it was the clams. Sheila struggles with her career. The new cop on the block wants to tango.
Trying to remember what happened during her blackout, Sheila discovers who she killed and that Lisa wants to get baptized. While covering her tracks with Joel, Eric and Abby are gathering the tools they need for a rebellious act.
Joel and Sheila panic, having to deal with Anne's paintings, a deadline to stop the dangerous clams from spreading, and on top of it all standing in the way of a rocket launcher.