Generally Saiki Kusuo no Psi Nan is very clever with its humor but there were some running gags that dragged the show down. Toritsuka constantly trying to harass female students and Saiki messing with his plans isn't funny. It seemed to be making light predatory behavior. Also what's with all the male characters trying to look for dirty magazines (reguardless of whether or not they are present) whenever they visit each other's houses? The only time it actually makes sense is when Kaidou's mom is looking for them in his room. And Teruhashi's brother? His infatuation with his sister feels more creepy than funny.
Overall though, the show is excellent. Saiki's constant sarcastic monologue and fourth wall breaking contributes a lot to the unique feel and humor of the show. The way his powers over complicate his life instead of helping him is a nice change of pace to other shows. All the characters are over exaggerated anime stereotypes, and the show isn't afraid to make fun of anime tropes. It's very self aware to the point that characters are conscious that they are watched by an audience. I've never seen anything so wonderfully weird, but it's a shame that there seem to be no boundaries of what it'll make fun of.
Overall though, the show is excellent. Saiki's constant sarcastic monologue and fourth wall breaking contributes a lot to the unique feel and humor of the show. The way his powers over complicate his life instead of helping him is a nice change of pace to other shows. All the characters are over exaggerated anime stereotypes, and the show isn't afraid to make fun of anime tropes. It's very self aware to the point that characters are conscious that they are watched by an audience. I've never seen anything so wonderfully weird, but it's a shame that there seem to be no boundaries of what it'll make fun of.