I've seen this at least 5 times. John Mulaney's delivery is genius. I really think you can see this echoed in a lot of skits online nowadays- the way he frames his jokes and his intonation have spread into mainstream comedy. He can spin a very mundane topic into cry laughter. In particular, his commentary on the Catholic Church is very funny- he knows how to poke fun at his own upbringing and personality in a way that doesn't come off as attention seeking.
