Dr. Adams asks Sam to participate in a clinical trial in an effort to regain her memories, but then the trial is "cancelled" just as Sam remembers probably one of the most important memories in her life.
Samantha's boss, billionaire Winston Funk, arrives at his twice-a-year visit at Chapman & Funk... and proposes to Samantha! And Samantha has no recollection of her past, secret (especially from Andrea) intimate relationship with Funk.
Turns out Todd has forgotten to mention that his roommate in London is a girl. Funk's ex-wife returns and Sam, whose affair with him broke their marriage, decides to reunite them. But then Sam discovers his old romantic e-mails.
Samantha's amnesia causes to a misunderstanding which leads a certain important couple to think she's racist. So Samantha decides to make Frank her first black friend. Tony is caught kissing a man and Andrea thinks it's all over now.
Sam ponders over the idea of using the invitation she got from Todd send her for his gallery exhibit and wonders what kind of message she'll be giving by attending with someone else.
Samantha runs into her billionaire-ex Winston Funk and starts to question her life. Her mother proposes a trip to Vegas. However, Samantha's amnesia covers her own past in Vegas... Andrea tries to shine the image public has of her.
Sam is late from her new first date with Todd, who then gives her one last chance. Andrea thinks Sam should go for Funk instead. And Funk just happens to need Sam to meet a senator at the exact time of Sam and Todd's date.