Ana receives a call from her mother, who tells her that her grandmother is dying. Despite her hatred for her, she returns to Alicante alongside Rafa to pay her and the rest of her family one last visit before her death.
Ana decides to volunteer in a convent in a effort to move on from Mario, but wants to do so by giving sandwiches to the poor instead of washing the floor.
Between her job and Instagram, Ana has her hands full. Things seem to look bright for her when she's has a minor role in an American production featuring Brad Pitt, but things go south when she passes out and sees her grandmother.
Ana is awarded with the 'Number 10 Woman of the Year' and assists the ceremony alongside Rebeca to receive it, but Rebeca's presumed delayed pregnancy keeps hindering the two.
Ana tries to seek help for her libido when her incapacity to be excited after her breakup is preventing her from doing a good performance on a scene for a television show.
It is finally revealed what happened to Mario: he suffered an accident in La Sierra, while thinking of how to tell Ana that the movie had been canceled. While the group tries to help him recover from his amnesia, Ana celebrates his return.
Ana Milán lives happily with her fiance, Mario, and is about to star in a movie to be directed by him. Her life falls into a downward spiral when he mysteriously goes missing.
After accidentally calling a fat fan who attends the same gym a 'cow' on Twitter, Ana and her friends try to find her in the gym at all costs so she can apologize.
Ana prepares to move on from Mario by quickly marrying and old friend of hers, Adolfo, who has returned to Spain to stay. However, the bachelor party goes all kinds of wrong.