Nancy is diagnosed with asthma. Secretly from her mother, she refuses conventional treatment and relies on the methods of Dr. Dedorio, who promises a quick recovery.
The school shows an educational film about where babies come from, but Jesse misses everything because of his mother. Polly opens a repair hospital for spoons.
Jesse is constantly write off Freddie's homework, as others see Jesse as a moocher and refuse to help. Nancy is dating a nice guy from a private school, but her friends don't believe her.
Nancy is afraid of getting sick on the eve of the sports Olympics and is trying insanely to protect herself from germs. Jesse gets a minor nose injury and uses it to his advantage.
The school holds a competition for the best science project. Penny and Nancy test insect repellant, Jessie and Vinnie force their parents to do a project for them, and Freddie is forced to work with Polly on her spoon project.
A textbook meets Jessy with answers for all tasks. He becomes a high achiever on mathematics. Nancy tries to make friends with Penny pretends to be, that hears badly.
Nancy and the other girls dress up like a famous singer. Mr. Besser is annoyed by this and introduces a school uniform. Jessie and Vinnie plan to get their ears pierced.