Casshern awakens to find his world reduced to a corrosive wasteland. Lost in a future he does not recognize, he struggles to stay a step ahead of those who wish death upon him.
An encounter with the mysterious Lyuze offers Casshern a fragmented glimpse of his role in the Ruin. After stumbling upon a community of "dying" robots, he discovers the true depth of his infamy.
Akoes warns Casshern against a life spent running from the past. When Friender arrives to make the assassin pay for his sins, Casshern chooses a path that could terminate his own existence.
Beautiful Sophita is feared by robots who wish to live as long as their decaying bodies will allow. Fighting makes her feel alive, and Casshern's special abilities make him a foe she could fight forever.
Lyuze reveals her reason for hating Casshern, who offers her a chance for revenge. When robotic bandits attack Ringo and Ohji, Casshern comes to their rescue, but his rampage terrifies those he hopes to save.
Casshern desperately seeks to unravel the mystery of his dark past. An altercation with Dio, his robotic mirror image, could provide answers to his many questions - or at least get him killed.
Lizbell is obsessed with building a giant bell to remind the world that beauty still exists. She scavenges parts from decaying robots, and Casshern's pristine body could be the final piece of the puzzle.
A rescue attempt by Casshern lands him at the bottom of a graveyard for abandoned robots. While a sweet - but simple - young girl tends to his wounds, Casshern hears whispers that Luna may still be alive.
Dio's mission to assemble a robot army is interrupted by the appearance of Dune, a formidable warrior who was once Luna's bodyguard. Elsewhere, Casshern continues his search for Luna.
Friender receives help from a caravan of robots and humans after Casshern is trapped beneath falling debris. But when the canine's new allies unearth the man who killed Luna, the situation takes a violent turn.
The search for Luna leads Casshern and Friender to Margo, an artist who refuses to let the Ruin destroy his spirit. Casshern finds inspiration in the artist's vision, but there are those who would rather see him dead.
Dying robots far and wide herald the saving grace of Luna. Meanwhile, Lyuze is disturbed to notice that Ringo has begun to rust, and Casshern is confronted by the monster who ordered him to Ruin the world.