8/10
This movie is important now, in this time of increasing advances in genetic sequencing.
27 January 2015
Warning: Spoilers
What I most enjoyed and loved about The Perfect 46 was after almost every scene I was left with a question in my mind about the ethics of scientific discovery. As a scientist, I was questioning my own work and pursuit of a new therapy for a debilitating autoimmune disease and the implications of my work. One of the main derivatives of the disease I study is an underlying genetic risk for the disease. There are specific genes that increase susceptibility for the disease in children and although, the subject of The Perfect 46 borders eugenics, the concept of trying to eliminate genetic risk associated with disease does seem like an appealing therapeutic approach. A 'pseudo-dating' genetic screening site may not be the best answer however.

From scene to scene I questioned what I would do in each of the conflicts Jesse Darden, the lead, would face- from a scientist and from a citizen perspective. This movie is important now, in this time of increasing advances in genetic sequencing. Ethical issues about what can and should be done with the accumulation of big data from large genetic sequencing studies needs to be addressed. The Perfect 46 thoroughly portrays how our technology is advancing faster than our understanding of its implications.

From an artistic perspective, I thoroughly enjoyed the simplicity and nod to retro artifacts in most of the locations in The Perfect 46. It was also interesting to see the character portrayal of a scientist as someone who became quite power and business driven. There are of course many of those types out there, as there are introverted academics that enjoy their quiet magnificent discoveries from behind the lab bench.

The Perfect 46 is a well-written, well-directed film that integrates a highly technical scientific discovery in to a refreshing question answer dialogue driven by an unexpected scientist character. This film is a treat to watch and I highly recommend it if you're in to or want to learn more about the repercussions of advancing technologies like this new era of next generation sequencing.
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