The murder of a best-selling true crime novelist sends Jane and the team on a hunt for a serial killer detailed in the author's final manuscript, which also features lightly fictionalized versions of the FBI team.
Roman's clues lead to a billionaire hypochondriac with stem cells that could cure Jane, who is now on her deathbed. Patterson and Rich offer to trade the Book of Secrets for the stem cells -- but first they'll have to get it.
Jane and Weller's romantic getaway is cut short when the team must stop Madeline Burke's plans to blow up a building and crash a plane that turns out to be more than the average commercial airliner.
Patterson's father, Bill Nye, returns for a case that pits the team against a pestiferous foe. Zapata goes rogue with an old friend. Jane and Weller continue their search for the hooded figure.
The team discovers an international conspiracy when a deadly weapon is stolen. Jane supports Weller when someone from his past dredges up painful memories. Patterson and Rich contend with their newly released hacker accomplice.
A horrifying and vengeful villain threatens the FBI. Weller considers his priorities. Zapata and Reade try to navigate their living situation. Patterson explores a budding interest.
The team sets out on an international mission to stop an attack from spreading. Madeline attempts to turn the tables as internal conflict threatens relationships within the team.