(at around 16 mins) When Linda Stiles is introduced for the first time and is speaking about Sutter Cain's book, she takes her glasses off and folds them twice.
After he get's black ink all over his fingers and under his eyes, he starts making the map from the book covers but he doesn't have ink on his fingers, just under his eyes.
At the church, Simon fires his double-barrel shotgun three times without reloading.
It is highly unlikely that Trent could draw on his padded cell wall's with all the crosses with a single crayon and no ladder.
After they run over the kid on his bike, there was no damage to the car. In fact, all the dirt on the hood remained intact.
(at around 14 mins) When the axe-wielding madman is shot several times by police men, no visible bullet marks are made by the gunfire.
(at around 1h 11 mins) When Sutter Cane peels himself away to reveal the abyss, although most of his upper half is no longer "in reality" his shadow on the wall behind him remains perfectly intact.
The bar code for the book being printed out in the open ending sequence is "1234567890"
Trent and Styles drive for at least 18 hours, through landscapes of cornfields in vast flatness, to reach the center of New Hampshire. New England isn't that big, and New Hampshire isn't that flat.