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In the premiere, host Conan O'Brien with his sidekick Andy Richter interview John Goodman, Drew Barrymore and Tony Randall.

Host Conan O'Brien and sidekick Andy Richter interview Christina Ricci, Tony Goldwyn and Micky Dolenz.

Host Conan O'Brien and sidekick Andy Richter interview Father Guido Sarducci (aka Don Novello) and Jackie Collins. Singer Des'ree performs her hit song "You Gotta Be".

Anderson talks about her Buddhist wedding, how the producers at first didn't want her as Scully and how quirky the shooting can get, while Conan assures her that no one had spat in her mug of water.