- He was thirty-nine years old when he directed his first feature film.
- Younger Brother of Argentine writer and producer Barbara Muschietti.
- Was set to direct The Mummy (2017) before dropping out due to creative differences.
- Both he and his sister studied at Universidad del Cine in San Telmo, Buenos Aires, Argentina.
- He is the second Latino director ever to direct a comic book film The Flash (2022) after Guillermo Del Toro directed Blade II (2002).
- He was reported among the front runners to direct a Masters of the Universe remake.
- He was going to direct Bird Box (2017) for Universal Pictures before the rights went to Netflix.
- He is rumored to direct the suspected and unwanted remake of Jaws (1975).
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