- Has been good friends with Omar Epps since their childhood.
- Graduated from the School of Performing Arts, NY and from Howard University
- His first son, Shawn Howell, is named after his brother Shawn Wayans and father Howell Wayans
- Son of Elvira Alethia (Green) and Howell Stouten Wayans. Brother of Dwayne Wayans, Keenen Ivory Wayans, Damon Wayans, Kim Wayans, Nadia Wayans, and Shawn Wayans. Also has sisters Elvira, Diedre, and Vonnie.
- Marlon was originally slated to play Robin/Dick Grayson in Batman Forever (1995) when Tim Burton was considering directing it, but once Joel Schumacher ultimately took the helm, his vision for the character did not jive with placing Marlon in the role and he instead cast Chris O'Donnell.
- Has two children with girlfriend Angelica Zackary
- Hosted the Best Of Comedia short film screening at the 2007 Just For Laughs International Comedy festival where he treated the audience to an insightful lecture on the history of the short film and its relevance in contemporary comedy film making.
- Cousin of Craig Wayans. Uncle of Damon Wayans Jr., Michael Wayans, Cara Mia Wayans, Kyla Wayans, Jolie Ivory Imani Wayans, Keenen Ivory Wayans Jr., Nala Wayans, Bella Wayans, and Damien Dante Wayans.
- Has two children, a son named Shawn Howell and a daughter named Amai Zackary.
- (July 23, 2009) Celebrated his 37th birthday at the Le Baron nightclub in Paris, France with a few of his G.I. Joe: The Rise of Cobra (2009) co-stars.
- Friends with Duane Martin, and Pamela Anderson.
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