- On November 29, 2000, he was attacked with a stun gun by his personal assistant, David Malloy, and was then robbed.
- His sarcastic Hollywood Reporter sketch on Saturday Night Live (1975) did not endear him to SNL alumnus Eddie Murphy when Spade did a joke in which a photograph of Murphy, whose career had started to falter, was shown and Spade quipped, "Look children, a falling star--make a wish.".
- Has a tattoo of cartoon character Calvin, from Calvin and Hobbes, on his left bicep. Sean Penn gave him the tattoo.
- On August 26, 2008, Jillian Grace gave birth to a baby girl, named Harper. David Spade, who had a brief relationship with Jillian, was confirmed as the father.
- Has been friends with Ellen DeGeneres since the 1980s when he was just starting out in comedy and she was somewhat successful. When they first met, Ellen invited him to her home for what he initially assumed would be a date, but their mutual friends informed him he was not exactly her type. The two would laugh about it in subsequent years, with Spade recounting this on one of his many appearances on DeGeneres' talk show, after she had been publicly out of the closet for a long time.
- Brother-in-law of fashion designer Kate Spade. Kate was married to his older brother, Andy Spade, who is president of Kate Spade Designs.
- David's father left his family when David was still was very young. Years later, his stepfather, a war veteran, committed suicide.
- Stated in an interview after the death of his good friend Chris Farley that he was concerned about his lifestyle and the choices that he made.
- Charged by the police in his home state of Arizona with reckless jet-skiing (2001).
- Received his Bachelor's degree in business from Arizona State University in Phoenix, Arizona (1986).
- He was so smart in third grade, he got moved up to the fourth grade for some of his classes.
- Is very sensitive to sunlight.
- His idol when he was young was James Garner. Spade used to watch him on The Rockford Files (1974), before co-starring with Garner on 8 Simple Rules (2002).
- David Spade's characters drive the same type of car in Tommy Boy (1995) and Joe Dirt (2001), a 1967 Plymouth GTX.
- Has played Danny Woodburn's son on 8 Simple Rules (2002), although he is actually four days older than him.
- He was awarded a Star on the Hollywood Walk of Fame at 7018 Hollywood Boulevard in Hollywood, California on September 5, 2003.
- Admitted on his official Twitter account that he made his very first trip to Europe with Grown Ups (2010) co-stars Chris Rock, Adam Sandler and Kevin James. They went to England, Ireland and Germany to promote the film before its European opening. (July 2010)
- Has two tattoos done by two-time Oscar winner and friend Sean Penn, one being a tribute to his late co-star and best friend Chris Farley.
- Auditioned for In Living Color (1990).
- Close friends with Heather Locklear, Chris Rock and Adam Sandler. Friends with Aaron Eckhart, and Jimmy Fallon.
- When [George Segal] received a star on The Hollywood Walk of Fame, Spade spoke at his ceremony.
- In 2014, Spade made a guest appearance on The Goldbergs (2013), which featured his former Just Shoot Me! (1997) series' lead, George Segal.
- During his first season on Saturday Night Live (1975), he appeared only three times.
- Once worked as a skateboard shop employee.
- Has German, English, Irish, Scots-Irish/Northern Irish, and Swiss-German ancestry.
- Born on the same day as actor/comedian John Leguizamo. He also shares a birthday with the following celebrities: Alex Trebek, Willem Dafoe and Danny Glover.
- In 1987, he performed on Fox's The Late Show (1986) and was offered a spot as a rotating host by the producers upon Joan Rivers' departure, but declined.
- Tended to perform in films and Saturday Night Live (1975) skits with the late Chris Farley.
- Is also a stand-up comedian.
- Is the youngest of three sons of Wayne Spade and Judy Todd. Brothers are Bryan Spade and Andy Spade.
- Was one of the guests at Lindsay Lohan's 19th birthday party on July 2, 2005.
- Has been commercial spokesman for Sierra Mist soda and Capital One credit cards.
- Was a member of the Sigma Alpha Epsilon fraternity in Arizona State University.
- Attended and graduated from Saguaro High School in Scottsdale, Arizona (May 1982). A fellow graduate was J.R. Moehringer.
- Attended Scottsdale Community College, before transferring to Arizona State University.
- Has more than two million Twitter followers.
- Was going to be on the George Wendt role in The Naked Truth (1995).
- Best known by the public for his role as Dennis Finch on Just Shoot Me! (1997).
- Although his birthday is on July 22nd, his star sign is Leo.
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