- TV commercial for Ducks Unlimited (2000)
- Print ads for the National Rifle Association ("I'm the NRA") (1999)
- TV commercial for Safeguard soap
- TV commercial for AT&T Long Distance ("You will" series) (voice) (1993)
- TV commercial for Lipton tea (1995-1997)
- Print ads for Revlon's Chaz Cologne for men (1979)
- Starred on Broadway in Herb Gardner's play "A Thousand Clowns," July-October 2001.
- TV commercial (voiceover) for 1-800-GORVING (October 2003)
- TV commercial for Chrysler PT Cruiser (2004)
- TV commercial for MSNBC (voice over) (2004).
- TV commercial for Pepi
- Print ads for RJ Reynolds' Salem 100s cigarettes (1977).
- Voice-over artist for the Go RVing ad campaign for several years.
- Tv ad voice over for Florida Orange Juice.
- TV Commercial voice over for NCAA. 2008
- (March 8, 2009) Narrator of the "Kingdom of the Blue Whale" on the National Geographic Channel.
- TV commercial for Close-up Toothpaste (1970s)
- TV commercial for Right Guard Anti-Perspirant (1971)
- (March 2012) TV commercial "The Value of a Home" for Coldwell Banker Real Estate (voiceover).
- (2008) Co-host, with Anthony Robbins, of an infomercial for the "Tony Robbins Ultimate Edge" coaching program. Also appearing are Brooke Burke, Serena Williams, Mark Burnett, Brett Ratner, Pat Riley, Donna Karan, Quincy Jones, 'Tom Terwilliger', Dan Caldwell and 'Dana Scott'.
- (January 23, 1989) Guest on "Live on Five".
- (April 2014) TV commercial "Where Home Begins" for Coldwell Banker Residential Real Estate (voiceover).
- (2016-present) TV commercials for American Advisors Group (AAG) reverse mortgages. In April 2023, AAG was acquired by Finance of America (FOA) Companies. Selleck's commercials for FOA reverse mortgages began appearing about a year later.
- (1972) TV commercial for Dubonnet (with Farrah Fawcett)
- (1970's) Tv commercial for Amana Touchmatic Radarange
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