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When a top-secret weapon falls into mercenary hands, a wild-card C.I.A. agent joins forces with three international agents on a mission to retrieve it, while staying a step ahead of a mysterious woman who's tracking their every move.

When a top-secret weapon falls into mercenary hands, wild card CIA agent Mason "Mace" Brown will need to join forces with rival badass German agent Marie, former MI6 ally and cutting-edge computer specialist Khadijah, and skilled Colombian psychologist Graciela on a lethal, breakneck mission to retrieve it, while also staying one-step ahead of a mysterious woman, Lin Mi Sheng, who is tracking their every move. As the action rockets around the globe from the cafes of Paris to the markets of Morocco to the wealth and glamour of Shanghai, the quartet of women will forge a tenuous loyalty that could protect the world-or get them killed.—HEYUGUYS

At a location 150 miles south of Bogotá, Colombia, a drug lord presents criminal mastermind Elijah Clarke (Jason Flemyng) with a special decryption program drive that can access any digital system on Earth. Clarke double-crosses and kills him just as the authorities raid the mansion. Amid the chaos, Colombian DNI agent Luis Rojas (Édgar Ramírez) obtains the device. Luis contacts multiple spy agencies to sell the device for $ 3MM in cash, in Paris. CIA operative Mason "Mace" Brown (Jessica Chastain) is assigned to purchase the drive from Rojas. She heads to Paris with longtime partner Nick Fowler (Sebastian Stan), with whom she is also in a relationship. The deal goes south when German undercover BND agent Marie Schmidt (Diane Kruger) swipes the bag holding the money. Mace chases Marie, who escapes via the subway while Nick is confronted in an alley by Clarke.

At CIA headquarters, Mace learns that Nick was found dead in the alley. Her superior, Larry Marks (John Douglas Thompson), gives her his blessing to retrieve the drive by any means (he cant help her officially, but tells her to complete the mission on her own). Mace travels to London to recruit a longtime friend, retired British MI6 operative Khadijah Adiyeme (Lupita Nyong'o). Khadijah is an expert on cyber security and understands the true magnitude of the threat from the device. She agrees to come out of retirement, when she learns that Nick has been shot dead. Khadijah helps Mace track down both Marie and Luis. Rojas arranges to hand the drive over to Graciela Rivera (Penélope Cruz), a DNI psychologist with no field experience. Graciela was assigned to get Luis to relinquish the drive into her possession and turn himself in for processing by their agency. Marie is pushed to go after the drive by her boss, Jonas Muller (Sylvester Groth), who brings up how Marie's father was a senior BND agent whom she personally turned after discovering that he was a Russian mole.

Mace and Khadijah track Luis and Graciela to a market only for the DNI agent overseeing the hand-off to turn on Luis and Garciela and kill Luis. before dying, Luis gives Graciela a phone only she can open that tracks the drive. Both Mace and Marie chase the thief (The DNI agent, who now has the drive), who escapes. Marie takes Graciela to a safe house with Mace and Khadijah arriving shortly thereafter. Khadijah points out they all want the drive and are better off working together. The four track the thief to Morocco (using Luis's phone), apprehending him and taking out rival mercenaries before handing the drive over to Marks. While celebrating over drinks, news breaks of planes crashing, and cities hit by massive power outages-indicating the drive is in terrorists' hands. They return to the safe house to find Marks dead. After escaping from a CIA assault squad, the women realize they have been framed for Marks' death and the theft of the device.

Under interrogation, the thief reveals that the recent incidents are all part of a "demonstration" for prospective buyers at an illegal black-market auction in Shanghai. The group infiltrates the auction where Mace is shocked to discover that not only is Nick alive (Nick tries to explain how he escaped and is only trying to secure his living post the CIA), but is secretly Clarke's mole in the CIA. The group fails to prevent him from obtaining the device, but a mysterious Chinese woman (who was posing as the director of the auction house and authenticated the drive before handing it over to Nick) helps them escape the auction. She identifies herself as Lin Mi Sheng (Fan Bingbing), and explains that the drive was used as bait to allow her agency to identify the criminals in attendance. She also tells Mace that Marks had been on Clarke's payroll (Marks knocked out the power and crashed the planes, before Lin Mi and her team reached there and killed him), and that she took the device from Nick (And substituted it for a decoy) during their escape.

Nick is beaten by Clarke's men for bringing a decoy device. He then captures the group, revealing that Clarke has Muller, Khadijah's boyfriend Ahmed (Raphael Acloque), and Graciela's family as hostages. Nick executes Lin's elderly father in front of the group, while Muller and Ahmed are executed on camera. Lin agrees to travel with Clarke and hand over the drive personally to spare Graciela's family. The other women overcome their grief to realize Lin is transmitting her location through a camera in her glasses. Arming themselves, they rescue Lin, shoot Nick, and destroy the drive before getting arrested.

Two months later, Nick, now promoted to a senior rank in the CIA for killing Clarke, returns home to find Mace and the group waiting for him after escaping from custody. Nick passes out from a drug in his drink, and is told he will pay for his crimes by spending the rest of his life in a foreign prison. The women go their separate ways but suspect they will somehow reunite to fight the corruption of their various agencies.