Throughout the entire story line, whether playing as Leon or Claire, the characters are shown in cut-scenes to be using only their regular pistol weapons (Matilda for Leon, SLS 60 for Claire) regardless of whether or not the player actually has those weapons or not. Also, even if such weapons are upgraded with new attachments acquired throughout the game, the pistols are still shown in cut-scenes in their completely unaltered form as well.
After Claire gets to the orphanage to rescue Sherry, Claire will run into Chief Irons. Just as Chief Irons comes out the door, quickly pause the game and click "Skip". This will skip the cut scene and show Chief Irons eyes still moving in weird directions just before it skips.
This game is set in 1998. However, when playing as Leon, he is driving a 2007 Jeep Wrangler the very beginning of the game.
A 2006 Chevrolet Impala can be seen in the Background.
RPD Chief Brian Irons uses a Smith & Wesson Model 329PD to threaten Claire in the RPD parking lot. That model was not available until 2 years after the game's setting.