Mack comments that he does not want to die where no one can hear him scream. This is a reference to the tagline of the 1979 film Alien: "In space, no one can hear you scream."
Coulson mentions "objects in space." This was the name of an episode from one of Joss Whedon's other sci-fi shows Objects in Space (2002).
Pruitt Taylor Vince, Rya Kihlstedt, and Eve Harlow were all in Heroes Reborn (2015). Kihlstedt and Harlow played mother and daughter.