The song was released on March 23, 2007 by Epic Records as the second and final single from the album.
"Me Haces Falta" is a Latin pop and R&B song about self-loathing. Its instrumentation consists of drums, cello, bass and guitar.
An accompanying music video for the song was directed by Sanji.
"Me Haces Falta" was included in the set list of Lopez's co-headling tour with Anthony in 2007.
Chris Willman of Entertainment Weekly praised the song's lyrics, but dismissed the song's production, stating that it does not live up the song's "florid, romance-novel lyrics".