The song that bookends the episode is Michael Pinder's "Have You Heard" from The Moody Blues' 1969 album "On The Threshold of a Dream." On the album, as in the episode, the peaceful song is presented in two parts, with a dramatic interlude between. The song's lyrics deal with the difficulty in identifying that a dream is not reality, much like in the Framework's virtual world.
This is the first episode to be both written and directed by the same person. The closest to this was Pilot (2013), which was co-written and directed by Joss Whedon, but not on his own.
Visual effects were used throughout the episode, including to depict the Triskelion building within the virtual reality of the Framework, as set up for the next pod of episodes for the season. The digital model of the building used by Industrial Light & Magic for the film Captain America: The Winter Soldier was given to the series' effects team for use in this shot
Self Control is Jed Whedon's directorial debut. This is the first episode to be both written and directed by the same person.
The sleeping gas that Daisy is considering using on the base appears to be Methoxypropane, which used to be used as an inhaled general anesthetic. Though it is strange that S.H.I.E.L.D. would be using that, they have access to technology and medications not available anywhere else in the world. Methoxypropane hasn't been used in several decades since the discovery of safer and more effective inhaled anesthetics such as Desflurane, isoflurane and sevoflurane. However those are usually just used for medical procedures, the chemical used by the Russian government in the Beslan siege in 2002 is believed to be a derivative of fentanyl, in an aerosolised form. It rendered a large group of people unconscious, but was also responsible for many deaths.