Simmons mentions that Hotch's team (from the mother series Criminal Minds (2005) was involved in the crackdown of an organ trafficking ring in New York City in 2009. This is a reference to a real, large scale anti-corruption probe by the FBI in the states of New York and New Jersey, known as Operation Bid Rig, which included the first arrest ever for organ trafficking in the US, that of Levy-Izhak Rosenbaum in Brooklyn.
Though this episode was first aired after the premiere, it was actually the fourth episode in order of production, following Love Interrupted (2016) (second) and De Los Inocentes (2016) (third).