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In the season six premiere, the entire staff at Chicago Med adjusts to the new normal of the pandemic. Dr. Choi, Dr. Lanik and April fight on the front lines. Dr. Halstead and Hannah face a troubling reality. Dr. Charles tries to clear the air with his daughter following recent developments.

A new head of the ED is announced and not everyone likes the choice. Dr. Manning makes a stand for her patient which has repercussions. Dr. Charles tends to his family

Dr. Charles and April team up to take on a mysterious patient in the ED. Dr. Halstead is forced to make a life-or-death decision for one of his trial patients. Dr. Marcel is confronted by his past when a former acquaintance is brought into the ED.

Dr. Marcel and Dr. Manning lay everything on the line to assist a sick woman. Dr. Halstead faces an uphill battle in getting participants involved in his clinical trial. Dr. Choi clashes with a patient who demands absolute perfection of himself.

Dr. Halstead's drug trial continues to be successful. Anna receives life changing news. Noah finds himself in a place even April cannot help.

Dr. Choi helps a patient with chronic pain find a solution. Dr. Halstead considers a new path. Dr. Charles and Anna bond over a scary situation.

Halstead runs into trouble when one of his trial patients falls ill. His own stress and symptoms have Choi struggling to get through the day.

Ethan hires an old Navy colleague to join him in the ED. A final custody hearing threatens to separate Daniel and his daughter. Maggie must make a choice that will change Auggie's life.

As Manning deals with her own trauma, she steps in to help a mother in need. Archer continues to stir the pot with more than one doctor. A patient comes to Med needing immediate treatment but doesn't want it from them.

Crockett deals with a patient who ends up having more in common with him than he thinks. Will and Ethan clash over a pregnant patient with an irregular heartbeat.

Ethan teams up with an unexpected person to treat a famous tennis player who is afraid his career might be over. Goodwin's new protocols cause a stir.

Archer and Choi go in to the field but the scene brings war flashbacks. Carol's condition worsen and Manning tries to get her enrolled in Halstead's drug trial.

An auto accident sends Goodwin into a spiral as she tries to help a young boy and his mother. Natalie's secretive behavior begins to draw the attention of Dr. Marcel and Dr. Halstead.

Third-year med students begin their rotation in the ED and Maggie keeps a careful eye on one of them. Natalie, whose mom's health takes another decline, tries to cover up how she broke the rules to treat her.

Crockett worries he made a surgical error when a recent transplant patient comes in with complications. Carol is once again in distress. Will and Natalie must take action to right their wrong.

Carol receives a second chance at life when a new heart becomes available. Ethan and Dean find themselves in hot water with an old patient. Will faces the consequences of the stolen trial medication.

Will Halstead returns to Med to help Goodwin with a secret investigation. Archer and Charles deal with twins who insist on being identical inside and out. Stevie and Dylan treat a young patient with sickle cell anemia.

Vanessa and Archer disagree on how to handle the victim of a motorcycle accident; Scott and Charles deal with a UNICEF negotiator with repressed trauma; Hammer and Halstead treat a high schooler with Addison's disease and a clingy mother.

Scott and Halstead deal with a dishonest patient whose lupus is in remission; a wealthy donor makes inappropriate advances toward Hammer; Vanessa, Marcel and Charles try to convince a young woman to have life-saving surgery.

Charles helps Dylan with a longtime patient who was recently diagnosed with schizophrenia. Stevie, Maggie and Vanessa investigate the legitimacy of a cancer patient's diagnosis. Crockett is caught off-guard. Will pitches a new medical technology.

Dylan and Charles treat patients suffering from Glass Child Syndrome and misdiagnosed ADHD. Crockett has to navigate hospital politics when he cares for the daughter of a transplant surgeon. Will and Stevie must lay egos aside to help save an elderly patient.

Stevie's personal and professional worlds collide when her mother becomes her patient. Dylan's history with the father of a patient interferes with his perception of a case. Crockett's allegiances are challenged when his patient's liver is a potential match for one of Dr. Blake's patients.

Marcel helps Blake replace a patient's liver; Taylor tries to prove herself; Halstead continues to pursue the truth about Cooper; Choi gets closer to returning to life in the ED.