Town vs Gown is based on an actual event that takes place in Cambridge (UK) each year. Mark Hampton had the idea for the film when he first attended the Town vs Gown event in January 2014. A year later he returned to film the fight scenes at the actual Town vs Gown venue.
The members of the Town squad seen training in the film are actually played by real-life Gown boxers from the Cambridge University Amateur Boxing Club.