Jane Villanueva is a religious young Latina woman who goes to college in Miami whose life takes a turn for the unexpected when a doctor mistakenly artificially inseminates her during a checkup. Jane's mother Xo, who became pregnant with Jane at a very young age, fears that Jane will be destroying her life by deciding to bring the baby to full term while Jane's traditional religious grandmother, Alba, encourages Jane to do what she chooses. The biological donor is a married man named Rafael Solano, a former playboy and cancer survivor who is not only the new owner of the hotel where Jane works, but was also her former teenage crush. Petra, Rafael's amoral and scheming wife, learns of the mistake and plots her own agenda. Petra is also involved in an affair with Roman Zazo, Rafael's best friend, who is under investigation by Jane's police detective boyfriend, Michael, and who also deals with Jane's unexpected "condition" in his own way. Meanwhile, the doctor who inseminated Jane, Dr. Luisa Alver, who is Rafael's younger sister, is distraught over learning that her wife cheated on and left her. Elsewhere, Rogelio de la Vega, who is a famous TV star and Jane's biological father, shows up to wanting to make contact with Xo... and is not aware of Jane's existence.
—Coco.B