We follow the journey of James Cole, a time traveller from a post-apocalyptic future, who heads to the present to stop a plague that will eventually decimate the human race.
Time Traveller James Cole's search for information about a mysterious organisation known as the Army of the 12 Monkeys leads him to a mental institution in 2015.
Cole and Dr. Railly face off with the Army of the 12 Monkeys when both discover the Night Room -- an off-site, black ops lab that houses the virus that will one day destroy the world.
After the events in the Night Room, Cole automatically returns to 2043 and finds that the timeline has been altered. He meets Jones, who has no idea who he is.
The Core that powers the time machine is fading. To get Cole back from the past, Jones must convince her former colleagues at the military operation "Spearhead" that her mission is worth saving.