When a commercial airliner lands and stands silent, CDC agent Ephraim Goodweather investigates the plane to find that the passengers are infected by a vile plague.
Eph and Nora work on a weapon to kill the strigoi, but Setrakian puts the group at risk by searching for an ancient text, while the Master introduces a new breed of creature and taps Kelly to control it.
Fet and Dutch grow closer on a mission to make sure neighborhood buildings are clear. Meanwhile, Eph and Nora perform experiments on their new patients; and Kelly begins her search for Zack.
Gus and Vaun wage an attack on Palmer as Eph struggles to connect with Zack. Councilwoman Justine Faraldo vows to bring her extermination policies to the other boroughs.
Eph and Nora finally see their lethal virus in action; Fet takes the security of Red Hook into his own hands; Dutch and Setrakian set off for Staten Island to question Fitzwilliam.
Eph alters his appearance so he can leave the city, which makes Nora a reluctant parent for Zack. Meanwhile, Dutch and Nora negotiate with Justine to get Fet out of jail.
Eph returns to New York intent on going after the individual responsible for his friends' deaths. Meanwhile, Setrakian and Fet launch an attack on the Master using Fitzwilliam's tip; and Dutch has a surprise visitor.
Eph must protect Zack against a surprise intruder into Red Hook. Gus convinces the Guptas to make a difficult choice. Fet and Setrakian set out to acquire the Lumen but discover they are not the only potential buyer.
Justine takes drastic measures to counter a surprise invasion. Nora and Fet perform a useful mission while Eph and Setrakian face off against an old foe.
Eph and Dutch work to execute Eph's plan against Palmer. Meanwhile Fet & Dr. Martinez accompany Setrakian on his search for the Lumen's true owner. And Councilwoman Feraldo makes a bold move in her quest to take New York City back from the Strigoi.
Gus helps the Guptas get across the border; Fet, Nora and Eph look all over the city for Dutch, who's in a life-or-death struggle with Eichhorst; Setrakian meets a familiar face while searching for the Occido Lumen.
The Lumen's auction starts in 24hrs. Setrakian seeks the Ancients backing. Gus seeks allies from his past. Zach's Grandparents are found, leaving Eph with a choice. Eldritch discovers the "White" has an unexpected price, to Eichhorst's delight.
Setrakian and Fet battle for possession of the Occido Lumen, and gain a surprising new ally. A massive attack imperils Eph, Nora, and Zack's escape from New York.
