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When her boyfriend dumps her before their exotic vacation, a young woman persuades her ultra-cautious mother to travel with her to paradise, with unexpected results.

Freshly dumped by her musician boyfriend the same day she gets fired from her job, rudderless thirtysomething Emily Middleton finds herself with two non-refundable tickets to Ecuador. Unwilling to lose the trip of a lifetime, she turns to the only person left to accompany her: her idiosyncratic, phobic, cat-loving mother Linda. The dream holiday soon turns into an Equatorial nightmare when the mother/daughter duo gets conned and abducted in broad daylight. To stay alive, scaredy-cat Linda and impulsive Emily need to set aside their differences and navigate through dense jungle thickets. Can they make it happen?—Nick Riganas

Emily Middleton is an entitled and self-absorbed millennial who spends much of her time taking selfies and posting them online to show people that she has a happy life, although it's actually unfocused. She scrambles to find a travel companion for a non-refundable trip to a beach resort in Ecuador that should have been a romantic getaway for her and her musician boyfriend Michael--but he has just broken up with her. Emily is able to convince her initially-reluctant long-divorced mother, proverbial crazy cat lady Linda Middleton, to accompany her, asking her solely in not wanting to drink alone, and upon discovering that Linda, in her youth, had a sense of joie de vivre no longer evident in her now seemingly overly cautious life. Beyond her cats, Linda dotes on Emily's brother, proverbial geek Jeffrey Middleton, who not only still lives with her but never leaves home in his agoraphobia and she does everything for him. While Linda is befriended by retired couple Ruth and Barb at the resort, Emily catches the eye of James and believes he could be her vacation fling. Emily may not be able to find out after she and Linda, in reluctantly accompanying Emily off the resort property, not only get stranded in the middle of nowhere without money or their phones, but are the target of violent extortionists. Needing to find their way to the safety of a US Consulate in a big city, they must work together to evade the extortionists--not the easiest thing for the two of them to do in their differences.—Huggo

After her boyfriend dumps her on the eve of their exotic vacation, impetuous dreamer Emily Middleton persuades her ultra-cautious mother, Linda to travel with her to paradise. Polar opposites, Emily and Linda realize that working through their differences as mother and daughter - in unpredictable, hilarious fashion - is the only way to escape the wildly outrageous jungle adventure they have fallen into.—20th Century Fox

When her boyfriend dumps her, Emily, a spontaneous woman in her 30s, persuades her ultra-cautious mom to accompany her on a vacation to Ecuador. At Emily's insistence, the pair seeks out adventure but suddenly find themselves kidnapped. When these two very different women are trapped on this wild journey, their mother/daughter bond is tested and strengthened while they attempt to navigate and escape from the jungle.

Recently fired from her job and dumped by her boyfriend, Michael (Randall Park), Emily Middleton (Amy Schumer) is determined to enjoy a previously planned trip to Ecuador. Learning of her relationship status from social media, her mother, Linda (Goldie Hawn), tells her to go home in order to move on, where she reunites with her agoraphobic brother, Jeffrey (Ike Barinholtz). Initially refusing, Linda agrees to go on the trip with her daughter.

In Ecuador, after they check into the hotel, Emily meets a man named James (Tom Bateman), and they begin a relationship. After one night of bonding with James, Emily and her mother take a sightseeing ride with James. During their ride, masked men in a white van ram James' Jeep and abduct Emily and Linda. James escapes. Emily awakens inside a cell and begins to panic, while Linda calms herself by reading men's magazines. The leader, Hector Morgado (Óscar Jaenada), has his nephew take both women away from the kidnappers' hideout and to another location. They manage to escape from their captors' car and stow into a passing truck, but not before Emily kills the leader's nephew by pounding his head with a shovel. The truck's driver then stops his truck and leaves them both in the middle of the jungle.

They find a phone at a nearby bar, where they call the U.S. State Department officer Morgan Russell (Bashir Salahuddin), saying that they are in peril, after escaping from the kidnappers and Morgan advises them to go to the US Consulate in Bogota, Colombia. They meet an American named Roger Simmons (Christopher Meloni), who agrees to help them find the consulate. After the three share a meal, Morgado and his men track them down. Morgado is about to kill them both as revenge for his nephew's death, but Linda distracts him while Emily retrieves a nearby spear gun with which to threaten him. As she retrieves it, she accidentally fires it, killing Morgado's only son. They manage to escape with Simmons onto a boat. Soon, however, they are forced off the boat when the captain detects another boat nearby that is looking for the two women.

Meanwhile, Jeffrey, learning that his mother and sister have been kidnapped, calls Morgan, saying he will join forces with the agents in order to find his mother and sister. Morgan reluctantly agrees. In Colombia, Emily, Linda, and Simmons hike through the jungle until Simmons falls to his death from a cliff. Later, Emily passes out from the effects of a tapeworm infestation. After a local village doctor removes the tapeworm from her body, Morgado and his men track them down again. They spot a zip line and decide to use it to escape. Unfortunately, the zip line is good for only one person. Linda forces Emily to leave her behind and is recaptured.

Emily safely arrives at the US Consulate. Determined to find her mother, she seeks help from two American women, Ruth (Wanda Sykes) and Barb (Joan Cusack), whom Emily met in Ecuador. Ruth and Barb take her to James, who was conspiring with Morgado, to the apartment where he is being interrogated for the kidnappers' location. With the ladies' help, Emily rescues her mother at the kidnappers' apartment. They try to escape in another truck, but Morgado intercepts them.

As he is about to kill Emily, Linda blows her dog whistle, summoning a dog that attacks Morgado. U.S. State Department agents arrive to arrest Morgado, and Jeffrey reunites with his mother and sister.

One year later, Emily and Linda take another trip to Kuala Lumpur, at which point Emily meets another man, who offers her a drink. Emily refuses, and she and Linda proceed to dance.