When Tobias returns to Sudden Valley and meets with Gob, Gob greets him with, "Good to see you, old friend!" taken (very loosely) from the song "The Sound of Silence," a running joke for season 4. In this case, the lyric "Hello darkness, my old friend," is modified; it was long referenced throughout Season 3 as well as an idea by the writers room that Tobias may be a black man with a rare skin condition.
Tobias (David Cross)' middle name is revealed as Onyango. Onyango is a name used by Luo People in Kenya and Uganda. Notably, Barack Obama's father's middle name is Onyango.
Signs on the set of Fantastic 4: An Action Musical have double sexual meanings: Fist! Poof! Drill! Stab.