The beginning of this episode starts with House looking through the eyes of a picture of Stephen Colbert, one of several references both Hugh Laurie and Stephen Colbert have made about each other on their respective shows.
Having taken LSD drugs, Dr. Chi Park hallucinates Chase is Roger Rabbit, and Dr. Jessica Adams is Jessica Rabbit with sexy red hair and a big bust. As Park remarks that "they're married," this refers to the "Roger Rabbit" films.
Will references Ross & Rachel from the sitcom Friends (1994). Hugh Laurie was in an episode of Friends (1994) starring opposite Rachel (Jennifer Aniston) in the season four finale 14 years earlier.
Billy Connolly's character voices support for House's green card marriage to Dominika. Billy Connolly previously starred in the short-lived sitcom Billy in which he played a Scottish teacher who enters into a green card marriage to stay in the US.
When discussing his other girlfriend with Dr. Adams, Michael B. Jordan's character Will says "For the first time in my life, I have somebody who needs me." This line is almost identical to the lyrics from For Once in My Life, a song written by Stevie Wonder, a famous blind musician.
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