Sarah Michelle Gellar is the voice of Stan's avatar and Alyson Hannigan is the voice of Steve's classmate who likes him. They both starred in Buffy the vampire slayer together as best friends.
When Roger is driving his limousine customers downtown, the bars and restaurants in the background are all well known establishments on Second Street in Harrisburg, PA. Some of the names are slightly changed.
The frat boys' bowling team name 'Lanes Addiction' is a nod to the band 'Jane's Addiction.'
The license plate on the limo is personalized BIGNLNG, or "Big and Long".
The line "Get away from him, you b*tch" + the exoskeleton Francine uses are both a homage to "Aliens".