- When one of their own is kidnapped by an angry gangster, the Wolf Pack must track down Mr. Chow, who has escaped from prison and is on the run.
- In the aftermath of the death of Alan's father, the Wolf Pack decides to take Alan to get treated for his mental issues. But things start to go wrong on the way to the hospital as they are is assaulted and Doug is kidnapped. Now they must find Mr. Chow again in order to surrender him to the gangster who kidnapped Doug in order to save him.—HeWhoShallNotBeNamed
- The further (mis)adventures of the Wolf Pack begin when Alan's outlandish behavior drives his father to death (literally) and he doesn't appreciate the gravity of the whole thing, so his family decides to send him to a place in Arizona where he can get help and ask his friends, Phil and Stu to be there when they tell him and convince him to go. So Phil, Stu, Doug, and Alan set off for Arizona. On the way, they're forced off the road and abducted. Their abductor explains that he grabbed them because he wants them to bring him their frenemy, Mr. Chow. It seems that Chow has gone underground and no one knows where he is. But it appears that he and Alan correspond with each other. So the man takes Doug and tells them to find Chow and bring him to him. Eventually he contacts Alan and they go to get him but he knows what they are doing, so he agrees to let them take him to the man, but first they need to break into the house to get something Chow needs to appease the man. But he double-crosses them and they end up in jail.—rcs0411@yahoo.com
- Alan Garner's latest mishap with his new pet giraffe gets him in very deep trouble--so deep that his father has a heart attack and dies in the middle of lecturing Alan about owning up to his mistakes. The Wolf Pack reunites at the funeral, and Alan's mother informs them that he has gone off his ADHD medication and is completely out of control. So the four of them stage an intervention and decide to send him to a rehab facility in Arizona. On the way there, their car is rammed off the road by a guy named Marshall. It turns out on the night four years earlier when Alan bought roofies for Doug's bachelor party, he inadvertently stalled a gold heist worth $42 million. Marshall wants it back, and has kidnapped Doug in order to send a message to the Wolf Pack. Their mutual acquaintance Leslie Chow, who made off with half that gold that night, has escaped from a Thai prison and is headed back to North America. But it appears that only Alan knows Mr. Chow's destination. This sends the Wolf Pack to Tijuana, Mexico, then back to Las Vegas. Can he foil the plot, make everything right for the Wolf Pack--and finally meet his dream girl?—halo1k
- Having proved that his social ineptness is dangerous beyond belief, off-his-meds Alan, the Wolf Pack's perpetual fourth wheel, is on his way to get treatment at a rehabilitation facility in Arizona. Doug, Stu, and Phil hit the road with him, but suddenly they're kidnapped by menacing crime boss Marshall for reasons that date back to Una notte da leoni (2009) and the boys' first visit in Las Vegas. Now, two years after the Thai mayhem in Una notte da leoni 2 (2011), the best friends have three short days to locate conniving thief Mr. Chow and a mountain of stolen gold bullion worth millions of dollars. This time, everything ends where it all began. Will the accident-prone Wolf Pack make the same mistakes yet again and live to tell the tale?—Nick Riganas
- Two years after the events in Bangkok, Leslie Chow (Ken Jeong) escapes from a maximum-security Klong Prem prison (37 Kms south of Bangkok), using a riot as cover. Meanwhile in America, Alan Garner (Zach Galifianakis) causes a 20-car freeway pileup after he purchases a giraffe and accidentally decapitates it on a low bridge. Alan's father Sid (Jeffrey Tambor), furious with Alan for never owning up to his mistakes (he got a call from the Mayor and had to write fat checks to fix this), dies of a heart attack in the middle of a lecture. After the funeral, Alan's brother-in-law Doug Billings (Justin Bartha) informs friends Phil Wenneck (Bradley Cooper) and Stu Price (Ed Helms) that Alan has been off his ADHD medication and is out of control. Stu is married to Lauren (Jamie Chung), Sid is married to Linda (Sondra Currie), Phil is married to Stephanie (Gillian Vigman), Doug is married to Alan's sister Tracy (Sasha Barrese).
The friends attend an intervention, organized by Linda. Alan is shocked and clearly believes that there is nothing wrong with him. Alan agrees to visit a rehab facility in Arizona, so long as "the Wolfpack" takes him there. Alan is moved by the prospect of a road trip with the people he considers himself the closest to. On the way to Arizona, Phil's minivan is rammed off the road by a rental truck and the group is taken hostage. They are later confronted by mob leader Marshall (John Goodman) and "African American Doug" (Mike Epps), his head of security.
Marshall tells them that Chow hijacked half of a $42 million gold heist that was executed by Marshall's gang 4 years ago. That night 4 years ago in Las Vegas, "African American Doug" sold the wrong drugs in Alan in the parking garage of a liquor store. "African American Doug" sold them the Roofies. Due to the events of that night Mr. Chow entered Las Vegas. A few weeks after that a Shiekh came in from Abu Dhabi and brought $42 million in gold bars to make some illegal investments in Las Vegas. Marshall intercepted the flight when it landed and went away with 2 vans, each with $21 million in gold. One van was hijacked by Mr Chow and the gold was never recovered. Then Mr. Chow was arrested in Bangkok and has no communication with anyone from outside the prison, except Alan. Now, Alan has been the only one to communicate with Chow during his imprisonment, Marshall deduced that the Wolfpack could locate him (since Chow escaped from prison 5 weeks ago and stowed aboard a freighter bound for the West Coast) and retrieve the gold. Marshall kidnaps Doug as collateral and gives the others three days to find Chow, or else Doug will be killed.
Alan sets up a meeting with Chow in Tijuana via email, Mexico, where Stu and Phil will hide and attempt to drug Chow (Stu writes the fake prescription and purchases the drugs in the US). However, Alan gives away their location to Chow (Alan is fidgety and Chow guesses that he did not come alone, as instructed), when he pressurizes him. Phil convinces Chow that they all miss him, and they go a bar together. Stu mixes the drugs in Chow's drink, but Chow can suspect that something is off. He forces them to confess they are working for Marshall. Chow explains his plan to retrieve the stolen gold from the basement of a Mexican villa he previously owned. Chow had villas in 3 different countries, but they were seized by the Government and auctioned off to the highest bidders. The current owner of the villa is a dot com wizard who doesn't stay there, as this is his vacation home. Even the help doesn't come on Sundays, so they only have the guard dogs to deal with. The gang puts the guard dogs to sleep with the drugs and Stu and Chow use their dog collars to enter the house and disable the security system.
Stu, Alan and Phil break into the house and successfully retrieve the gold, but Chow double-crosses them by locking them in the basement, rearming the security system and escaping in Phil's minivan. They are arrested but mysteriously released from the police station, where they are picked up by a limousine and taken back to the villa, where they meet up with Marshall.
They learn that Chow had lied to them; the villa was never his and the gold they stole was the other half he didn't get from Marshall. Marshall forgives them for their mistake but kills "African American Doug" for his incompetence and reminds them of their now two-day deadline. Marshall gives Phil his limo to track Chow. The group tracks Phil's phone, which was left in the minivan, outside a pawn shop in Las Vegas. The pawnshop owner, Cassie (Melissa McCarthy), tells them that Chow traded a gold brick for $18,000, far less than its usual sell rate of $400,000. Alan and Cassie develop feelings for each other in their short tryst.
Cassie told the Wolfgang that Chow took the number of an escort service, they call the escort service, but they refuse to say anything. So, they contact Jade, who was an escort in LA. Using Stu's former lover Jade (Heather Graham) as their contact, they learn that Chow is barricaded in the penthouse suite of Caesars Palace. Jade is now married to a surgeon named Jeff and is pregnant again. Alan connects with Jade's son from the previous marriage. He is now a grown-up toddler and was a baby when Alan saw him last 4 years ago and carried him all around Vegas in a baby sling. Alan tells the boy that he is his real father.
The trip inform Marshall about Chow's location, and are given till 6 am the following morning to bring Chow to a spot just outside Vegas. Phil and Alan sneak into his suite from the roof, but Chow escapes, jumping from the balcony and parachuting down to the strip. Stu catches up to Chow and locks him in the trunk of the limo that Marshall had lent to them. They take the gold and meet with Marshall, who releases Doug back to the group. Although Marshall initially promised to not harm Chow, he changes his mind and shoots through the trunk of the car, presumably killing him. Luckily, Alan had freed Chow through a backseat compartment just moments earlier.
Chow emerges from the limo and kills Marshall, allowing the Wolfpack to live because Alan had saved his life. He offers Alan a bar of gold as a gift, but Alan turns him down, and ends their friendship due to Chow's unhealthy influence on the group. As Chow sadly watches them leave, they go to retrieve Phil's minivan from the pawnshop and Alan makes a date with Cassie. Six months later, Alan and Carrie get married. Vowing to begin taking responsibility for his actions, Alan regretfully resigns from the Wolfpack, but would still like for the gang to hang out on occasion. As the four walk to the ceremony, a montage of clips from the previous films play.
The morning after the wedding, Alan, Cassie and Phil appear to have staged another wild party that they cannot remember. Stu emerges from the bathroom with breast implants and Alan remembers that the wedding cake was a gift from Chow, who emerges from the next room naked, laughing and wielding a Katana.
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