Plot

When House and Wilson bet on a boxing match and disagree over the outcome, Wilson gives him exactly one day to pay up or prove him wrong.

When House and Wilson bet on a boxing match and disagree over the outcome, Wilson gives him exactly one day to pay up or prove him wrong. House presses the boxer for more information to help prove his case and ends up attempting to breathe new life into the losing fighter's career. Meanwhile, the team begins to suspect House may have another type of drug problem.—Fox Publicity

Open with the testing of some sort of new missile. Immediately after the successful test one of the scientists who seems to be in charge of the project falls on the floor and begins having a seizure.

We see House doing some sort of exercise for his bad leg. It doesn't appear to be going well.

House walks into the team meeting chugging water. He doesn't seem all that interested in the patient. He references a second "interesting puzzle" and Wilson walks in demanding that House pay him $50 for a boxing bet. House bet on the underdog (Foley) but is convinced his guy took a dive. Wilson gives him one day to prove it. House leaves.

Thirteen and Taub give the patient (Dr. Lee) an MRI. Thirteen seems convinced karma is playing a role in someone who designs weapons for a living getting sick.

House meets Foley at a diner. The boxer is adamant that he didn't take a dive and assures House that he's just become a terrible boxer. He points out that nobody pays a 12 to 1 underdog to lose.

House is convinced Foley has a medical issue, showing Wilson a cell phone picture he says proves he has anisocoria. Wilson isn't convinced.

Ceaser, Lee's co-worker/boyfriend, corners House and says that he thinks he knows what's wrong with her, citing her last boyfriend was crazy.

Ceaser thinks she's being poisoned by the ex-boyfriend. The team starts treating her with charcoal.

Taub and Foreman find a box of empty liquor bottles at Lee's place. She swears she's not an alcoholic, that she's been saving them for a friend's art and has to hide them from a housekeeper.

The team realizes there is no reason an alcoholic would keep empty bottles. But Foreman still suggests valium for alcohol withdrawal.

Foley comes into the hospital for an EKG that ends up being normal. House thinks something is wrong with him but Foley wants to be left alone.

Lee has abdominal pain. Stress is suggested because of the two guys fighting over here, as is kidney issues. Taub points out that they probably need House, who is for some reason ignoring his pager.

Foreman asks Wilson to pay House and admit he's right for the sake of their patient. Wilson thinks it's a good thing that House is obsessing over something, even if it's not the primary patient.

We again see House struggle with a pretty basic leg exercise. We then see him cook a powder in a spoon and inject it into his arm. He's been doing it for some time.

Pancreatitis treatment did not help. The team has nothing. House walks in and asks them a question about his boxer. Taub ignores House and suggests a neurological condition for Lee brought on by an untreated UTI. Foreman hangs back and tells House he thinks something is going on and offers his help. House just walks out.

House goes to the gym and tells he thinks he can help Foley return to the form that helped him win his first 20 fights before losing his next five. House surprises him with an injection of epinephrine. He thinks this will drop Foley with a soft punch but nothing happens. Eventually Foley knocks House aside and walks away.

Lee crashes, this time with a heart attack. Ceaser (who is bedside) points out she is in fantastic shape.

Foreman asks Cuddy to step-in and help House for the sake of Lee. She doesn't seem interested.

Thirteen breaks into House's place just as he's injected his mystery powder and calls him an idiot. He tells her his leg has been getting worse and he didn't think he should up his Vicodin dosage. She knows it's not heroin, calls him an idiot, and thinks House must be playing a game of some kind. He tells her that he's been injecting an experimental drug that has re-grown muscle in rats. She calls him an idiot. Total idiot tally: 3.

Immediately after surgery to implant an internal defibulator Chase notices Lee is having vaginal bleeding. The next suggestion is a blood disorder of some kind. Foreman still thinks a toxin could be to blame. The team is concerned about House and Thirteen is conspicuous with her silence. She doesn't say anything about his self-medicating.

House doesn't seem to be making any progress and has runs out of the drug. He visits the scientist in charge of the study and after being assured that higher dosage shouldn't be a problem as long as the subjects are hydrated, House steals a few more baggies of the drug.

The latest symptom for Lee is bleeding from her mouth. The nurse says it looks as if her gums were burned.

Still no progress for House, who goes right to his stash of Vicodin. Wilson comes to visit, having been told about the drug by Thirteen. He tells Wilson he's stopped taking the drugs because they don't seem to be working. Wilson thinks House thinks all his problems are his leg, wanting to be able to cure his unhappiness.

The next guess for Lee is that she's suffering from exposure to radiation. They move her to isolation in order to give her a stem cell transplant. On the way Ceaser seems certain that couldn't be the case.

Waiting on the procedure Lee asks to see Ceaser. Foreman says it's too risky to bring more people into the room. They notice she's suffering from engorged genitals.

House stops Foley during a run and has him drink eight bottles of water. His latest guess is that Foley has a kidney issue that sent him to the canvas during the fight. It doesn't work.

House finally pays off Wilson, breaking some of his stuff in the process.

Inflammation of the genitals seems to indicate they were wrong, but since Lee's symptoms have stopped Foreman wants to continue treating for radiation. They are still at a loss.

House gets drunk at a bar and goes on a rant about why people consume alcohol. He picks a fight with a patron. Just before being punched in the eye House notices he is able to hold himself up with his bad leg.

The team wants to treat Ceaser for the same condition, telling him he also needs a bone marrow transplant. He says 'no,' and Chase points out this means he know what's been hurting her. They have figured out that he was poisoning her and she's finally better only because he hasn't been near her. They're having his place searched as they speak.

House is able to lift his leg in a way he never could before. He's moving around the house without his cane. He accidentally hits himself in the head with the cane and thinks of something.

House is hitting the heavy bag at the gym when Foley arrives first thing in the morning. House takes his cane and pokes Foley in the back of his neck. Within a second he falls to the ground.

Thirteen tells Lee that Ceaser was poisoning her because he found she was seeing yet another guy on the side. He'd been giving her Spanish Fly, which has an active ingredient which causes similar damage to radiation.

House tells Wilson he's figured out their bet. Foley has an abnormal growth of nerves in his neck caused by a tumor and the clinch before the punch is what knocked him down. He'll be fine but will never be able to box again.

House goes home and pulls the experimental medication out of the trash.

The episode ends with the scientist coming into the lab and fining one of the rats lying dead on the treadmill.