Though this episode is entitled Nebraska, the American Gothic scene that is recreated by the pull-back shot immediately following Dexter's first road trip kill features the Dibble House, in Eldon, Iowa.
In response to Dexter saying he would go to Portland, Oregon, Dexter's dark passenger brother says "That's a little predictable. Isn't it? Isn't that where all serial killers go?" This is in reference to the following serial killers who at some point were active in Portland, Oregon: Gary Ridgway (The Green River Killer), Keith Hunter Jesperson (The Happy Face Killer), Sebastian Shaw, Andrew David Edwards, William Perry Jackson, Richard Laurence Marquette, Randall Woodfield (The I-5 Bandit), Cesar Barone, Scott William Cox, Thomas Creech, Jeffrey Paul Cutlip, John Fautenberry, Levi Boone Helm (The Kentucky Cannibal), Homer Lee Jackson III, Randy Kraft (The Freeway Killer/Scorecard Killer), Gerald "Jerry" Walter McFadden (The Animal), Earle Nelson (The Dark Strangler), Todd Alan Reed (The Forest Park Killer), Robert Joseph Silveria Jr (The Boxcar Killer), Edward Bates Soper, Edward Delon Warren, Douglas Franklin Wright.
Scott Michael Campbell (Norm, the motel clerk) is growing cannabis. He also appears doing the same in House (2004) Euphoria: Part 1 (2006) (as Joe Luria).