Every episode of the show is named after a famous song. "P.Y.T. (Pretty Young Thing)" is a song by Michael Jackson.
When Dr. Avery starts working with Dr. Sloan in the plastic surgery area, he calls Avery "Mr. Green Eyes", when in fact Jesse Williams (Avery) has blue eyes.
Alexa Havins' real life husband Justin Bruening also guest stars on the show later on as the paramedic Matthew Taylor.