The lab calls Chase and tells him he needs to redo his drug test unless he's pregnant. Though this isn't the plot from this statement, certain types of testicular cancer can in fact give a man a positive pregnancy result.
The opposing players at Jamie's baseball game have the words "Davola's Pizza and Pasta" printed on the back of their jerseys. This is a possible reference to Joe Davola, an executive producer for the series.
Title "The Man Who Sailed Around His Soul" was a single by British 80s band XTC.
Opening theme song performed by Against Me!