Eric Cartman participating and running an illegal KFC ring is a direct parody of Scarface (1983). Many references are taken straight from the film.
The concept of a former KFC restaurant becoming a medicinal marijuana store mirrors that of a real life marijuana dispensary in the Palms community of Los Angeles, California. The store, called Kind for Cures, is abbreviated K.F.C. on its exterior signs and resembles the KFC fast food eateries in appearance, which has drawn national media attention to the marijuana dispensary. It was forced to repaint the familiar red and white striped exterior soon after opening. Located at 9850 Exposition Blvd., it opened in 2009 and closed in 2015. As of 2022 the building still stands, but is empty.
The "sorters" who are naked women is based on the movie American Gangster.
Randy putting his testicles into a microwave is a nod to Running Scared (1986) where a detective suggests it to a street cop as an insult.