Episode list

Rob and Chris Pratt discuss formative favorites, their time together on Parks and Recreation, and Rob's disastrous audition for Footloose

Rob and Earvin "Magic" Johnson discuss their shared history of the LA Lakers heyday, how Rob escaped by seaplane to catch the 1987 finals against the Celtics, and the origin of Earvin's nickname

Rob and Conan O'Brien discuss the difference between sharks and dolphins, how Elizabeth Taylor was able to cry on command, and why Conan thinks ghosts are overrated. Plus: we learn if Conan is actually Rob's boss or not.

Rob and Keegan-Michael Key discuss eccentric NFL names, the vocal mannerisms of Danny Glover, Keegan's role opposite Meryl Streep in the new Ryan Murphy movie Prom and so much more

Rob and Gwyneth Paltrow discuss their 30 year friendship, having Steven Spielberg direct your wedding video, and how Gwyneth has never really left Rob's guest room

Rob and Mike Myers discuss painting Colonel Sanders, shushing Paul McCartney, "who do you think you are" vs "who do you want to be," and the perils of getting another take from Quentin Tarantino

Rob and David Spade discuss SNL nerves, lost watches, and the infamous Spade/Farley fight on the set of Tommy Boy

Rob and Demi Moore discuss recording foley sounds for her new podcast Dirty Diana, shooting the courtroom scene from A Few Good Men, and reminisce about the effect director Joel Schumacher had on their lives

Rob and Dana Carvey discuss poltergeists in Montecito, Mickey Rooney's lost projects, and sleeping in the Lincoln Bedroom

Rob and Nick Offerman discuss their Midwestern roots, Nick's time coming up on the Chicago stage, the specificity of character names on Parks and Recreation, and the importance of being present

Rob and Caitlyn Jenner discuss the history of her many iconic photos, her lifelong journey to live authentically, competitiveness, fame and family

Rob and Nikki Glaser discuss her performance at Rob's Comedy Central Roast, filling in for Paula Abdul, getting sober, and moving back in with your parents

Rob and Alec Baldwin discuss tension on the set of Glengarry Glen Ross, a voicemail from George C Scott, the projects that got away, and their political ambitions (or lack thereof)

Rob and Michael Strahan discuss getting older, Michael Jordan vs Kobe, drawing strength from adversity, and the $100,000 Pyramid

Rob and Martin Short discuss making jokes at their manager's funeral, who got cut out of Three Amigos, dealing with hecklers, SCTV vs SNL, and the meanest thing Jiminy Glick ever said

Rob and Tiffany Haddish discuss buying a theater together in Dayton, OH, roller skating in the '80s, and Rob gives his advice for upstaging Nicolas Cage

Rob and Aaron Sorkin discuss The West Wing, a disastrous moment from A Few Good Men in London, and doing Chekov with Christopher Walken

Rob and Jane Lynch discuss non-traditional pet names, Transcendental Meditation, working with Christopher Guest, and discover they have much more in common than they expected

Rob and Maria Shriver take a deep dive on compassion, work ethic, family, succeeding in a boys' club environment, and the positive aspects of solitude

Rob and Jon Lovitz discuss the history of Jon's Saturday Night Live characters, the strange fate of his cat Mr Marc Stevenson, and roasting Arnold Schwarzenegger

Rob and Jerry Bruckheimer do a deep dive on Jerry's career in film and television, including Top Gun, Flashdance, the CSI franchise, Captain Jack Sparrow, and more

Rob and Eric Andre discuss beatniks vs hipsters, mean pranks vs funny pranks, and making the Eric Andre Show pilot in an abandoned bodega

Rob and Jo Koy discuss Las Vegas during the pandemic, pre-show rituals, keeping up with the Black Eyed Peas, and take a deep dive on Seattle sports and the Philippines

Rob and Jim Belushi discuss making About Last Night, the advice Belushi gave to a 12-year old Rob, the Blues Brothers, and creating a sitcom marriage

Rob and Catherine O'Hara discuss bad auditions, following in Gilda Radner's footsteps, Schitt's Creek's historic Emmy wins, and the secret inspiration for Moira's look

Rob and Michael J. Fox discuss the balance of realism and optimism, Transcendental Meditation, being in a jungle for six months with Sean Penn, and dissect some of Paul Simon's most cryptic lyrics

Ted Danson and Rob Lowe have watched the entertainment industry transform. Ted Danson joins Rob Lowe to discuss the incredible legacy of "Cheers," the optimistic comedy of "The Good Place" and "Parks and Recreation," his experiences working with Steven Spielberg and Larry David, learning that his show was canceled while touring the Sistine Chapel, and the importance of protecting our oceans.

It's a love-fest when old friends Robert Downey Jr. and Rob Lowe get together. Rob is talking to his former high school classmate and longtime friend: the great Robert Downey Jr. Hear them discuss their shared memories from Santa Monica High School, surviving the 1980s, the genius of Christopher Nolan, and growing from set-backs.

Rob wouldn't mind swapping lives with Hollywood legend Brian Grazer for a day. The prolific film and TV producer (whose credits include "24," "Arrested Development," "Apollo 13," and "A Beautiful Mind") joins Rob to discuss the future of Hollywood, how to revamp the Oscars ceremony, the differing worldviews of "The West Wing" and "24," his book on the power of face-to-face conversation, and his latest film, "Candy Cane Lane" with Eddie Murphy.

Rob and filmmaker Ed Zwick have so many great memories from shooting their 1986 film "About Last Night!" Filmmaker Ed Zwick (creator of "thirtysomething" and director of "The Last Samurai" and "Legends of the Fall") joins Rob to revisit "About Last Night," and discuss Ed's work with Tom Cruise, the death of a certain kind of adult drama film, advice from Morgan Freeman, and Ed's new book, "Hits, Flops, and Other Illusions: My Fortysomething Years in Hollywood" (out February 13th).

Cheryl and Rob have so much to catch up on. Cheryl Hines joins Rob Lowe to discuss the final season of "Curb Your Enthusiasm," Larry David's run-in with Elmo, how she would dress as First Lady, choosing your Secret Service code-name, Cheryl's mom's birthday at Thunder Down Under, and much more.

Tig and Rob are silent laughers. Comedian Tig Notaro joins Rob Lowe to discuss their shared obsession with the song "Do They Know It's Christmas?" by Band Aid, her foolproof method for testing potential TV show titles, her love for drama and despair, her podcast "Handsome," and her new comedy special, "Hello Again." Plus, Rob reveals a bit of White House trivia he learned shooting "The West Wing."

Kelly Ripa joins Rob Lowe to discuss getting "knighted" by Disney, the joys of working with her husband, why Rob was one of Kelly's favorite guest co-hosts, trying out the Oculus headset, Rob's 60th birthday party, her podcast "Let's Talk Off Camera with Kelly Ripa," and her big goal to get out of hair and makeup.

At long last, Rob's son Matthew Lowe is on the show. VC investor, attorney, and fisherman Matthew Lowe joins Rob to discuss golfing with his mom Sheryl Lowe in Hawaii, appearing in "The West Wing" as a kid, watching Dad's movies as a family, encouraging his father to join "Parks and Rec," sitting next to Rob in the iconic NFL hat photo, studying for the bar exam, how shooting their show "The Lowe Files" convinced Matthew that ghosts are real, and his predictions for the future of media.

Rob Lowe welcomes back one of his favorite podcasters and now radio host, Andy Richter. They get into Andy's new call-in show on SiriusXM, Howard Stern, how game shows are one of the last universal forms of entertainment, British comedy, and more.

Fred and Rob are so happy to be working together again on their Netflix show "Unstable!" Fred Armisen joins Rob Lowe to discuss the new season of "Unstable" (out August 1st), Fred's approach to playing Uncle Fester in "Wednesday," shooting "The Floor" in Ireland, dinner for Mick Jagger, Rob's field trip to the CERN particle accelerator, starring in the official music video for George Harrison's "My Sweet Lord," and much more.

Season 2 of "Unstable" is now streaming on Netflix. John Owen Lowe and "Unstable" Season 2 showrunner Andrew Gurland join Rob Lowe to discuss the new season of their Netflix show, the increasingly blurry line between Rob and John Owen's characters and themselves, catching up on "Real Housewives of New Jersey," the amazing unpredictability of Fred Armisen, the character they wish was serving as host for this episode, and much more.

Rob and Casey love talking movies. Casey Affleck joins Rob Lowe to discuss his new film, "The Instigators," the value of sobriety, the understated genius of Matt Damon, their first movie theater memories, the "Outsiders" audition process, actors as directors (and directors as actors), some excellent advice from Michael Caine, and much more.

Jamie and Rob want you to listen to your dreams. IT Cosmetics founder and podcast host Jamie Kern Lima joins Rob Lowe to discuss her journey from Denny's waitress to the founder of a billion-dollar cosmetics brand, finding inspiration in dreams, cheering yourself on, not taking rejection personally, and her new podcast, "The Jamie Kern Lima Show."

Lamorne and Rob had so much fun on the set of "Unstable" season 2 (out now on Netflix!). "New Girl" star Lamorne Morris joins Rob Lowe to discuss his role as Peter in "Unstable," the legacy of Chris Farley, how he prepared for the his film about the first episode of "Saturday Night Live," his Emmy-nominated work in the new season of "Fargo," some of the advice Rob gave to Lamorne on-set, and much more.

David and Rob are always on TV. "SEAL Team" and "Bones" actor David Boreanaz joins Rob Lowe to discuss the final season of "SEAL Team" on CBS, nearly drowning in alligator-infested waters, their memories of working with Rob's brother Chad, getting discovered while walking his dog, and much more.

Rob and the Chernin brothers love a good high school movie. "Always Sunny" writers and "Incoming" filmmakers Dave and John Chernin join Rob Lowe to discuss their new high school comedy film on Netflix, their admiration for Danny DeVito, Rob's classmate who might have inspired Sean Penn's character in "Fast Times at Ridgemont High," other projects featuring the "Always Sunny" bar (including "St. Elmo's Fire"), bone-fishing with Marlon Brando's son, and much more.

Cook, author, and now television host Erin French joins Rob Lowe to discuss her unique restaurant, The Lost Kitchen, the signs of a good local restaurant, the secret to a perfect croissant, hibernating in the winter, weeping in the dining room, and why she asks diners to make reservations via postcards (seriously!). Don't miss her new show, "Getting Lost with Erin French," on the Magnolia Network.

Jeff and Rob talk film, marriage, and life. Film legend Jeff Bridges joins Rob Lowe to discuss why Jeff's marriage is an inspiration for Rob and Sheryl, Jeff's home being caught in a deadly mudslide, the upcoming Tron sequel, their favorite films, memories of filmmaker Peter Bogdanovich, and the new season of Jeff's show, "The Old Man."

Country superstar Keith Urban joins Rob Lowe live from the SiriusXM Garage studio in Los Angeles to discuss their first concerts, getting to Nashville, their sobriety journeys, Keith's new album, and much more. Plus, Rob and Keith answer questions from fans about their marriages and bucket-list items.

Actor and filmmaker Mark Duplass (The Morning Show) joins Rob Lowe to discuss working with family, their mutual friend Jennifer Aniston, searching for Bigfoot, and his new shows, "Out There: Crimes of the Paranormal" and "Penelope." Plus, Mark asks Rob for advice about empty-nester anxiety.

Jay and Rob love their celebrity impressions. "Saturday Night Live" alum Jay Pharoah joins Rob Lowe to discuss hosting the Fox game show "The Quiz with Balls" and showcase his spot-on impressions of Denzel Washington, Will Smith, Charles Barkley, SNL creator Lorne Michaels, and more. Jay's new comedy special, "Jared," is now streaming on YouTube.

Kim and Rob have had front-row seats to Hollywood's transformation. Legendary Hollywood journalist Kim Masters joins Rob Lowe to discuss the state of entertainment, the once-in-a-generation star power of Tom Cruise, a hilarious memory from the "West Wing" cast, the future of the Disney company, the scarcity of great sitcoms on streaming services, and much more. Plus, Rob talks to a fellow Daytonian about curiosity.

Actor and filmmaker Mark Duplass (The Morning Show) joins Rob Lowe to discuss working with family, their mutual friend Jennifer Aniston, searching for Bigfoot, and his new shows, "Out There: Crimes of the Paranormal" and "Penelope." Plus, Mark asks Rob for advice about empty-nester anxiety.

Rob is in his happy place talking baseball with Jomboy. Baseball commentator and content creator Jimmy "Jomboy" O'Brien, who has amassed over one billion total views on his Jomboy Media channel, joins Rob Lowe to discuss the 2024 World Series, the secret to effective lip-reading, baseball's return to the center of culture, how Jomboy Media combined backyard baseball with reality television to create the Warehouse Games, the passing of baseball icon Fernando Valenzuela, and much more.