First episode to not feature Katherine Heigl (Izzie).
Ellen Pompeo was pregnant with her first child when season 6 began filming. This is the reason for her lack of screen time for the first quarter of the season. This is also the first episode she recorded after giving birth.
Derek incorrectly calls time of death as "12:35 AM" medical professionals use 24 hour time specifically so that they don't have to indicate am or pm. He should have called it as "24:35" or "0:35" depending on what he was taught.
Katherine Heigl (Dr. Isobel Stevens) did not appear in the episode even though she was credited. However she was mentioned many times.
Every episode of the show is named after a famous song. "I Saw What I Saw" is a song by Sara Groves.