"Biological Didn't Bother" is the first single released from Shaquille O'Neal's second album, Shaq Fu: Da Return
The song is dedicated to Shaq's stepfather, Phillip A. Harrison
The single was a minor success, making it to number 78 on the Billboard Hot 100
The music video portrays a simplified biography of O'Neal's early days living in Newark, New Jersey. It discusses his estrangement from his biological father Joseph Toney, with whom he would not reconcile until 2016. O'Neal refers to his stepfather Phillip A. Harrison with the lyrics, "Phil is my father."
The song is referenced by Roger in season 7 of American Dad! during the episode "Seasons Beatings".