- A mute bartender goes up against his city's gangsters in an effort to find out what happened to his missing partner.
- Berlin. Forty years from today. A roiling city of immigrants, where East crashes against West in a science-fiction Casablanca. Leo Beiler (Skarsgard), a mute bartender has one reason and one reason only for living here, and she's disappeared. But when Leo's search takes him deeper into the city's underbelly, an odd pair of American surgeons (led by Rudd) seem to be the only recurring clue, and Leo can't tell if they can help, or who he should fear most.
- In 2035, Leo (Alexander Skarsgard), a bartender mute from a childhood accident (He ran into a boat propeller while swimming in the lake. Leo could have been treated with surgery, but his Amish mother didn't approve of it as it was against their beliefs), works at a Berlin strip club owned by Maksim (Gilbert Owuor). Leo dates waitress Naadirah (Seyneb Saleh), who is secretly in desperate need of money. Leo is Amish and doesn't like technology. To stay in touch, Naadirah gifts him the oldest mobile phone that she could find on the market. After rowdy customer Stuart (Noel Clarke) sexually harasses Naadirah, Leo assaults him.
At Leo's apartment, Naadirah attempts to tell him something important but is distracted when Leo shows her a bed he has been carving as a present for her. Moved, Naadirah has sex with him. Elsewhere, Maksim's mobsters meet American surgeons Cactus Bill (Paul Rudd) and Duck (Justin Theroux), who run a black-market clinic to fix bullet wounds and other injuries that cannot be reported to the authorities. Bill pressed Maksim to provide forged documents to leave Berlin with his daughter Josie (Mia-Sophie). Duck, however, enjoys Berlin and runs a cybernetic surgery side business. Bill is a US military solider who is absent without leave. If he is caught, he will be imprisoned. Duck is attracted towards young girls, but Bill warns him to keep away from Josie.
Taunted by Stuart at the club, Leo fights him again and gets fired. Unable to contact Naadirah, Leo asks her roommate Luba (Robert Sheehan) for help, but she refuses. Following an address Naadirah wrote on his notepad, Leo finds Oswald (Dominic Monaghan). Oswald is a pimp who manages appointments for all of Maksim's prostitutes. Oswald assumes Leo works for Nicky Simsek (Jannis Niewohner), Maksim's underling who is skimming money from Maksim's prostitutes. Oswald pays Leo Simsek's cut so he can deliver it to Simsek. Meanwhile, Leo is receiving messages from Naadirah's phone about her location.
Bill is confronted by the Military Police Sergeant who reveals that Naadirah is willing to pay them real money to arrest Bill.
Leo sees Josie leaving Maksim's bar with someone and follows the cab in Maksim's car. He reaches another bar where Simsek is having dinner with Maksim's henchmen. Leo meets with Simsek, who is babysitting Josie. Leo befriends Josie and leaves the money from Oswald and a note incriminating Simsek in front of Maksim's henchmen.
Leo gets lucky. He is ordering food at a digital kiosk and needs to enter a phone number. He only had Naadirah's number on his phone and enters it. Turns out, Naadirah was registered with the kiosk and her address was on the database. After tracking down Naadirah's address, Leo discovers Luba, who works as a prostitute under Naadirah's name. She is in love with Naadirah and jealous of Leo. Using Naadirah's contacts on the phone system on the fridge, Leo finds her mother by finding the number in the phone book and then looking up the address. Leo learns Naadirah is Josie's mother; Cactus Bill, her ex-husband, is responsible for her disappearance. Bill had entered Naadirah's house when she was with Leo and had drugged her coffee. Naadirah passed out after having sex with Leo and that's when Bill picked her up from the bed and took her away, while Leo was knocked out cold.
Bill knows that Leo is looking for Naadirah. Leo messages Naadirah's number to ask for Bill's location. After Bill and Duck torture Simsek on Maksim's orders, Bill discovers Duck is a pedophile and has hidden cameras in the patient change rooms and observation rooms to ogle on them. Bill threatens to break Duck's arms if he ever touches any child. However, he becomes elated and forgives Duck when Maksim reports he has the forged documents ready for Bill. Bill celebrates with Duck, offering his house and his job to him, so Duck can close the clinic and stop working with kids. Venting his frustrations with Bill, Duck casually reveals he was the one who had been anonymously texting Leo. A security guard stops them for a casual theft, and Bill threatens to kill the guard. When Duck intervenes, Bill strikes him. Upset by this treatment, Duck texts Leo that Bill is headed for Maksim's club. Leo uses a support beam from the bed he made to beat up Maksim's group, including Maksim, and takes Bill's forged documents.
Then Leo heads to Bill's house, after getting Bill's address from Maksim. In Bill's house, Leo finds a wounded Simsek and Naadirah's corpse in a bag. Bill murdered Naadirah, who was saving money to pay to have him deported by the military police. Naadirah wanted custody of Josie and getting Bill deported was the only way for her to do that. After killing Simsek, Bill attacks Leo, who impales him with his own knife. Duck later appears, refuses to take Bill to a hospital, and instead, turns the surveillance camera installed in Josie's room towards Bill's face, threatening to make him see Duck sexually assaulting her.
Duck knocks out Leo and implants an Electrolarynx so he can make Leo confess for killing Bill. When Leo refuses, Duck takes him to the bridge in the one photo Leo has of Naadirah. Duck took the picture on a trip with Naadirah and Bill. Leo refuses to apologize, takes a breath and throws both of them into the water. Drowning Duck, Leo swims to the surface, finds Josie at the bridge's edge and uses his new voice to warn her away from the danger. Both of them safe, Leo tells Josie he will take her to her maternal grandmother.
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