When Castiel is hesitant about going with the prostitute, Dean says 'Dayenu', which is a Hebrew word. It is the name of a very famous Passover song of giving thanks. In this context, it roughly means 'Be grateful to God for these gifts'.
Sam and Dean share no scenes in this episode.
In a deleted scene for this episode Sam and Lindsey had sex.
The FBI Agent names used by Dean at the police station is a character from Midnight Run (1988). Alonzo Mosely was also used there by someone impersonating Mosely, an actual FBI agent.
The actress who plays Chastity in this episode, Katya Virshilas, also plays Lust in the Season 3 episode, The Magnificent Seven (2007).