- A game-show-obsessed woman and her estranged sister work together to help cover their mother's gambling debts.
- Tightly-wound, game-show-obsessed Anne must team up with her chaotic sister Jenny to help pay off their mother's gambling debts. When Anne's beloved dog is kidnapped, they set off on a cross-country journey to get the money they need. To do so, they must tap into Anne's skill set by turning her into the game-show champion she was always meant to be.
- Anne, a tightly wound, game show-obsessed young woman, receives a call notifying her that her gambling addict mother has fled to Macau. This news reunites her with her estranged and reckless older sister, Jenny. Jenny, who had previously been living in her car, temporarily moves in with Anne. One night while Anne is watching her favorite game show, Can't Stop the Quiz, Jenny secretly records Anne answering every question at remarkable speed and uploads it online. The video goes viral overnight, drawing the attention of a loan shark to whom Anne and Jenny's mother owes $80,000. Tracking down Anne, he demands that she pay off her mother's debt and informs her that he has kidnapped her pet dog, Mr. Linguini, as ransom. Anne blames Jenny for the mishap and asks her to use money she won from a lawsuit against a restaurant chain to pay the ransom; however, Jenny reveals she lied about winning the case and that she cannot pay off the debt. Instead, she encourages Anne-whose video gained the attention of Can't Stop the Quiz casting directors-to go on the show and win enough money to get Mr. Linguini back.
Prior to the audition for the show, Jenny dislocates her wrist at a bar. While waiting at the doctors office and reminiscing about old times, Anne admits to defecating into a hole when staying at their cousins' house in Burbank one summer when they were younger, due to her being too uncomfortable and unwelcome to do so inside the house. Jenny comforts her, saying that the cousins never liked their side of the family anyway, claiming it to be the reason why they never stayed with them again. During the audition, Anne, initially nervous about being in front of a crowd of people, tries to leave before it begins, but Jenny gives her some calming pills that are later revealed to be hallucinogens. After being given other pills to calm the effects of the first one, Anne does well at the audition, impressing the crowd and the producers.
The next morning, Jenny congratulates Anne and reveals to her that this was all part of her plan to become a self-described life coach, stating that she lied about lying and really did have a large check coming in from her lawsuit and she tricked Anne because she knew that she would not have gone on the show without her thinking she had no other choice. Angered, Anne insults Jenny, to which the latter retaliates saying that she was the one that has always been looking out for her, bringing up the time when Anne defecated into the hole, revealing she did not dig the hole deep enough and the other cousins found it. Jenny covered for Anne, telling them that she was the one to do it and this was the reason they never allowed Jenny, Anne, and their mother to stay with them again.
Anne returns home and her cantankerous neighbor, Francine, invites her into her home for a cup of tea. Francine tells Anne that she has lived a long time and that worrying about and trying to get other people to like you is a waste of time. Anne receives a call saying that she has been invited to go onto Can't Stop the Quiz, and decides to go on the show with Francine as her partner. Meanwhile, Jenny negotiates with the loan sharks and eventually steals Mr. Linguini back. Anne shows strong disdain for Ron, the long-running returning champion on Can't Stop the Quiz, and finishes a distant second to him after the first round. When Jenny shows up with Mr. Linguini, she convinces Anne to finish the game, and persuades the producers to let Anne have the dog with her to calm her. After the second round, Anne is closely behind Ron. When the third round is chosen to be a game of charades, Anne switches partners and plays with Jenny instead of Francine. On the winning word, they share a heartfelt moment as Anne admits to Jenny that she is her hero.
Anne wins the game, and goes on to win 93 consecutive games, holding the record for longest streak. She is later hired as a writer on the show. Jenny's check comes in from her lawsuit and the two of them pay off their mother's debts. Jenny also purchases a Malibu mansion where Anne and Jenny now live together.
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