Anne Dudek was pregnant when they were shooting this episode.
The episode won an Emmy Award for Outstanding Sound Mixing for a Comedy or Drama Series (One Hour).
The sleeping medication that Wilson gives House is marked on the bottle as zolpidem 200mg. This is highly inaccurate, as the highest dose available is 20mg.
Foreman says that deafness can be replicated with a $3 pair of earplugs, but this is false. Earplugs only dampen sound by 32 decibels, while severe to profound deafness is a reduction of more than 70 decibels.
After Amber suggests that House play the patient some music, House shows up to the patient's room with a boom box blasting Public Enemy's song "Fight the Power." This is a direct reference to Spike Lee's movie "Do the Right Thing," in which the character Radio Raheem is often seen with a boom box playing the same song.