The daughter of the brewery owner asks Amanda Redman and Dennis Waterman whether they are a couple. In the series they are not, but in the 80s they actually did have a relationship in real life,
When Dr. Lilwall says, "Thought I'd stop by, give you the bad news mano a mano" he probably thought he was saying man to man. The phrase actually means "hand to hand".
They refer to the Wellesley Park Private Clinic. While there is no such hospital in London, there is the Wellington Hospital, which had a famous fertility clinic, and Wellesley was the original surname of the Duke of Wellington.
James Bolam and Rachel Fielding had previously appeared together some 17 years earlier in S1 E1, Found and Lost (1991), of Second Thoughts (1991).