Plot

The team works to save someone close to a central character's heart. The key is inside House's head, but he is in a bad way himself.

Wilson pretended he was Amber's husband so he could authorize Amber's transfer to Princeton-Plainsboro. On the way to the hospital, Wilson suggested that they freeze Amber's heart to give House more time to diagnose her, but he soon began questioning why she was with House on the bus.

The team bought some time for a diagnosis by freezing Amber's heart, then went to work. The fact that her heart was slowed down made the diagnosis more difficult. House sent Kutner and Thirteen to Amber's house to look for anything that might have made her sick, and Taub came to House alone to ask him what chance there was that he and Amber hooked up during the time House couldn't remember. At the very least, he wondered whether they might have done any drugs together. House didn't answer, Taub did the tox screen. It was negative.

Inside Amber's House, Kutner and Thirteen found a video clip on Amber's laptop that showed her and Wilson getting ready to record themselves having sex on her couch. Thirteen shut it off, saying it wasn't medically relevant. She thought the team shouldn't be treating Amber because they were too personally involved.

In his office, House had a dream of Amber walking in and giving him the idea that they might have hooked up. She suggested maybe she'd always had a thing for him and he'd always had a thing for her. She poured a glass of sherry and climbed onto his lap (in the dream!) and House woke up, startled. House wanted to unlock the memory from his brain by undergoing deep brain stimulation, electric impulses applied to his brain.

House pulled Thirteen aside and told her to get over whatever it was that bothering her and "do your job." Amber's liver was failing. House wondered about that sherry that Amber poured in his dream. It was a clue about which bar they'd been at the night before, Sharrie's. House took Wilson there and the bartender tossed House the keys to his motorcycle as soon as he walked in the door. The bartender (yes, that was Fred Durst, the Limp Bizkit dude!) said that seemed like he was into the woman he was with at the bar. House had a flash of himself walking with his arm around Amber. Wilson wondered about the "seemed into her" line.

Back at the hospital, Thirteen's job was being affected by her feelings about them treating Amber. This opened the door for quick background on Kutner: He was 6 when his parents' business was robbed and the robbers shot his mother and father. "Everyone dies," he told Thirteen.

House was starting to let Wilson affect his treatment of Amber, much to the dismay of Foreman. He believed House was letting Wilson's emotions get in the way of the treatment. He later went to Cuddy and told her that House was going to kill the patient. Cuddy and Foreman restarted her heart and possibly damaged her brain in the process.

In a restroom meeting, House confronted Thirteen and suggested that she was all torn up about Amber because she couldn't stand watching a young doctor die because of her own fear that she was living with Huntington's Disease but hasn't been tested. In a following montage, Thirteen drew her own blood.

When House finally started making decisive calls about how Amber should be treated, Cuddy told Wilson to back off and let House do his job. He then asked House to do the deep brain stimulation, risking his life to save Amber's. House agreed to do it. In a bizarre scene of electric shocks to the brain, House pieced together the night's events. He remembered the bartender taking his keys because he'd had too much to drink. He asked to make a phone call and called Wilson's house but Wilson was on call and Amber answered. She agreed to pick House up from the bar, but he coaxed her into having one drink with him. House stumbled out of to bar to ride the bus home and left his cane. Amber found it and brought it to him on the bus. A few minutes later, the crash happened.

House recalled Amber sneezing, but it wasn't as simple as the flu. It was the medicine she was taking for it. She had amantadine poisoning. Wilson reasoned that the crash destroyed Amber's kidneys, which took away her ability to process the drugs. But House told him the amantadine binds with proteins and dialysis couldn't clear it out of her bloodstream. "There's nothing we can do," House told Wilson. House's memory led up to the moment of the crash, and he had a seizure.

Once it was clear that Amber was going to die, Cuddy suggested to Wilson that they wake her up so he could have a few more hours with her. Wilson broke down. When Amber awoke, he explained to her what happened and she understood that she was going to die. She said she shouldn't have gotten on the bus. Wilson told her it wasn't her fault (did he think it was House's fault?). The team visited Amber and said goodbye, then Wilson laid in bed with her and hugged her until the bitter end.

Back in House's room, he laid unconscious when he saw Amber in one last dream sequence on the bus. He told Amber he should have been the one who was dead. He was afraid Wilson was going to hate him, and Amber told him he kind of deserves it. House suggested that he wanted to stay dead with Amber and didn't want to get off the dream bus "because it doesn't hurt here. I don't want to be in pain, I don't want to be miserable. I don't want him to hate me." Amber told him he can't always get what he wants. House got up and walked out of his dream, waking up in his hospital bed with Cuddy next to him.

Meanwhile, Thirteen pulled her test results and saw that was positive for Huntington's. Taub rolled into bed with his wife. Kutner ate cereal while watching TV. Foreman met up with Chase and Cameron at a bar. Wilson went to House's room and stood outside, meeting eyes with House briefly before walking away. When he laid down in bed, Wilson found a note Amber left that read, "Sorry I'm not here. Went to pick up House."