- Two straight guys pretend to be gay in order to secure a Miami apartment. When both of them fall for their roommate Neha, hilarity ensues as they strive to convince one and all that they're gay whilst secretly trying to win her heart.
- After her parents' deaths, Neha Melwani lives in Miami with her aunt and rents out a room in her apartment to two seemingly-gay Indian men, photographer Kunal Chauhan and nurse Sameer Acharya. She introduces them to her departing gay boss Murli and falls in love with her new boss, Abhimanyu Singh. She will soon realize that she has two rivals for her new love--none other than Kunal and Sameer.—rAjOo (gunwanti@hotmail.com)
- Sameer Malhotra (Abhishek Bachchan), a nurse, and Kunal Chauhan (John Abraham), a photographer. Sameer likes in a motel and is looking for an apartment to shift into. Kunal was living with his friend, but now has to vacate the place and move into a new one within 2 weeks. They are both fun-loving, womanizing bachelors in Miami. They first meet at a friend's place after a night out with girls. They again bump into each other while looking for an apartment to rent. They fall in love with the same apartment; however, the owner Mrs Melwani (Sushmita Mukherjee) refuses to sublet it to them as her niece, Neha Melwani (Priyanka Chopra), will stay in the apartment alone. Mrs Melwani is looking to sublet the 2 vacant rooms in the apartment only to women. When a U.S. soldier mentions how much Sameer and Kunal remind him of his own relationship with his life partner, Sameer tries to convince Kunal to pretend to be lovers so that they may live in the apartment with Neha. Kunal initially refuses but agrees out of desperation. Their plan works as Mrs Meliwal agrees and they move in. They regret their decision when they meet Neha since they are attracted to her. The three become good friends, and Sam and Kunal fall in love with her. Sam makes up false narratives about they met in Venice. Sam is the feminine one, while Kunal is the more "manly" one. Kunal is not happy with Sam perpetrating the lies even deeper, but at this point even he has no choice but to go with the flow.
Sam tells Neha that he hasn't told his mother about him being gay. Neha lost her parents in a car crash when she was 9 years old. As Sam and Kunal continue the charade, Kunal convinces Sam to apply for a domestic partnership with him, as Sam is a US citizen and Kunal is not. If they file as a gay couple then the process for citizenship for Kunal will be completed within a year, whereas otherwise it can take up to 5 years for the same. Unknown to them, the approval letter is sent to Sam's conservative mother Rani (Kirron Kher), who lives in London. One day, Neha's boss, Murli 'M' (Boman Irani), announces that he is resigning his job as the editor of Verve magazine and will decide who should take his position. M has an offer from the competing Diva magazine (as their new editor in chief) and is on his way out. To impress her editor and get the job, Neha invites M for dinner at her house, telling him that she will introduce him to her gay and single friends (as M himself is gay).
Sameer's mother Rani, who lives in London, finds out that her son might be gay and is not pleased. A US immigration agent Javier visits them for a surprise inspection and joins the party. Chaos ensues when Rani arrives from London to confront her son about his newfound sexuality. Sam tries to deny his relationship with Kunal, but the immigration agent affirms that they are a couple. M becomes upset because Neha had told him Sam and Kunal were both single, and leaves.
The next day at Neha's office, M announces that Abhimanyu Singh (Bobby Deol) will be the new editor. Neha, heartbroken, returns home where she is consoled by Sameer's mother and in turn, she helps Rani accept her son's sexuality. Kunal and Sameer then help Neha with her on a redesign project, given to her by Abhimanyu.
While Kunal is out for a few days, Sameer takes Neha on a romantic outing. Later, he tries to tell Neha about their scheme and admit that he loves her, but Kunal overhears and stops him. While they try to figure out what to do, Kunal suggests that Sameer meet him and Neha that night at a local dance bar. Instead, Kunal takes Neha to a romantic dinner and movie. The next morning, Sameer is furious with Kunal.
Abhimanyu and Neha start dating, and Sameer and Kunal decide to team up to sabotage the relationship. Despite their efforts, Abhimanyu and Neha eventually fall in love. Sameer and Kunal redirect their efforts into frightening Abhi's son, Veer (Shrey Bawa), about his future stepmother, Neha. Neha discovers that Abhi plans to propose to her during a basketball game. She leaves and asks Kunal and Sameer what she should do. Kunal and Sameer are shocked and reveal that they are not gay and are in love with her. Meanwhile, Veer tells Abhi of his fears and begins to cry, asking his father not to marry Neha. During the game, Abhi hugs Neha and ends the relationship, citing Veer's discomfort. Neha tearfully turns out Kunal and Sameer from the apartment and resigns from Verve.
A few months later, Kunal and Sameer go to court to collect their resident permits and realize that they miss Neha. They find her at a fashion show and try to apologize, but she refuses to see them. Abhi shows up, and Kunal asks when their wedding is. Neha tells him that they broke up because Veer wasn't comfortable with her. Kunal and Sameer then admit the truth about their manipulations, infuriating Abhi and Neha.
Kunal and Sameer get on the stage and beg for Neha's forgiveness, with the crowd egging them on and asking them to get on their knees and give flying kisses to Neha. Then they are asked to kiss each other, and the guys refuse to do so. Neha and Abhi begin to turn away. At the last moment, Kunal forcibly kisses Sameer. Abhi is amazed and tells Neha that the guys were really her best friends, as he wouldn't have done that for her. Neha goes to them, and they make up.
Kunal and Sameer propose to Abhi for Neha. He agrees, and Neha and Abhi get married. Two months later, Neha, Kunal, and Sameer are sitting on the apartment's balcony, enjoying themselves. Neha asks them if they felt anything during their charade of pretending to be gay. Kunal and Sameer get defensive and Neha leaves saying "Sorry, touchy topic." Sam and Kunal, now alone, remember the kiss.
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