When Constantine carries off the temporarily heart-stopped Zari to the van through the horde of zombies, one of the zombies bears a striking resemblance to George A. Romero.
The classic Wilhelm Scream is heard when Mick throws the bus driver out.
Andrew Kasch wanted to plant some Easter eggs in the zombie horde. There are two: Trash from The Return of the Living Dead (1985) and Shaun from Shaun of the Dead (2004).
The episode's title is a reference to the book "I Am Legend" by Richard Matheson.
Mick mentions being in an prison transport. This most likely references the events of the end of Revenge of the Rogues (2015), in which he and Leonard Snart were being transported to Iron Heights after being defeated by The Flash, before being rescued by Leonard's sister Golden Glider.