It was originally meant to be a mini-series, but it was eventually changed to an anthology film.
The film won an Emmy Award for Outstanding Individual Achievement in Animation - animation.
The director of Segment III is Paloma Baeza, her husband is Alex Garland. He is the director of Annihilation (2018), Ex Machina (2014) and the writer of 28 Days Later (2002).
The film's writer Enda Walsh and the director of Segment III is Paloma Baeza are related to Cillian Murphy. Murphy played the main character in several plays written by Walsh. Baeza was a former actress and appeared in Sunburn (1999) with Murphy. She recommended Murphy as the male lead of the film to her husband Alex Garland, the writer of the film 28 Days Later (2002).